Evidence map›Paper›PMID 34375594›Full record

ArticleCurrent biology : CB2021

Mucus.

Abigail McShane, Jade Bath, Ana M Jaramillo, Caroline Ridley, Agnes A Walsh, Christopher M Evans, David J Thornton, Katharina Ribbeck

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 132 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites.American journal of respiratory cell and molecular biology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Observational
  11. A Coarse-Grained MARTINI Model for Mucins.Journal of chemical theory and computation · 2026
    Article
  12. Article
  13. Mucinase fromFrontiers in microbiology · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Metal Ion-Induced Cross-Linking in Mucin-Inspired Peptide Hydrogels.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Article
  19. Spatial self-organization of confined bacterial suspensions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Abigail McShaneDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02141, USA; National Science Foundation Graduate Research Fellowship Program.
Jade BathDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02141, USA.
Ana M JaramilloPulmonary Sciences, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Caroline RidleyDivision of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester M13 9PT, UK.
Agnes A WalshDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02141, USA.
Christopher M EvansPulmonary Sciences, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: christopher.evans@cuanschutz.edu.
David J ThorntonDivision of Infection, Immunity, and Respiratory Medicine, University of Manchester, Manchester M13 9PT, UK. Electronic address: dave.thornton@manchester.ac.uk.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02141, USA. Electronic address: ribbeck@mit.edu.
Massachusetts Institute of Technology · USUniversity of Colorado Denver · USUniversity of Manchester · GBU.S. National Science Foundation · US

Funding

TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Role of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL130938NIBIB NIH HHS R01 EB017755NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades. As a barrier, it lubricates surfaces, protects our cells from physical stress, and selectively allows the passage of nutrients while clearing out pathogens and debris. As a home to our microbiota, it supports a level of microbial diversity that is unattainable with most culture methods. As a reservoir of complex carbohydrate structures called glycans, it plays critical roles in controlling cell adhesion and signaling, and it alters the behavior and spatial distribution of microbes. On top of all this, mucus regulates the passage of sperm during fertilization, heals wounds, helps us smell, and prevents the stomach from digesting itself, to name just a few of its functions. Given these impressive features, it is no wonder that mucus crosses boundaries of species and kingdoms - mucus gels are made by organisms ranging from the simplest metazoans to corals, snails, fish, and frogs. It is also no surprise that mucus is exploited in everyday applications, including foods, cosmetics, and other products relevant to medicine and industry.

Indexed as

MicrobiotaMucusAnimalsIntestinesMucous MembraneNutrientsNutrients

Identifiers

PMID34375594
PMCPMC8759706
OpenAlexW4206719507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.