ArticleProceedings. Biological sciences2021
Plicidentine and the repeated origins of snake venom fangs.
Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 31 citations in OpenAlex.
- A description of dental microanatomy and implantation geometry in Chamaeleonidae.Journal of anatomy · 2026Article
- The histology of rhynchosaur (Diapsida, Archosauromorpha) ankylothecodonty.Journal of anatomy · 2026Article
- Rethinking thecodonty: the influence of two centuries of comparative dental anatomy on our understanding of tooth evolution.Biology letters · 2025Review
- Histological and histochemical characterisation of the salivary glands of the palatine fold and the mandibular venom gland of the Komodo dragon (Varanus komodoensis).Veterinary research communications · 2025Article
- Reconstruction of feeding behaviour and diet in Devonian ctenacanth chondrichthyans using dental microwear texture and finite element analyses.Royal Society open science · 2025Article
- Curving expectations: The minimal impact of structural curvature in biological puncture mechanics.Science advances · 2024Article
- The Phylogenetic Relationships of Major Lizard Families Using Mitochondrial Genomes and Selection Pressure Analyses in Anguimorpha.International journal of molecular sciences · 2024Article
- Dynamic finite element modelling of the macaque mandible during a complete mastication gape cycle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Armed to the teeth: The underestimated diversity in tooth shape in snakes and its relation to feeding behavior and diet.Ecology and evolution · 2023Article
- A conserved tooth resorption mechanism in modern and fossil snakes.Nature communications · 2023Article
- Using natricine snakes to test how prey type and size affect predatory behaviors and performance.Frontiers in behavioral neuroscience · 2023Article
- Does the model reflect the system? When two-dimensional biomechanics is not 'good enough'.Journal of the Royal Society, Interface · 2023Article
- Taking a stab at modelling canine tooth biomechanics in mammalian carnivores with beam theory and finite-element analysis.Royal Society open science · 2022Article
- Dental anatomy and replacement patterns in the early Permian stem amniote, Seymouria.Journal of anatomy · 2022Article
- Plicidentine in the oral fangs of parrotfish (Scarinae, Labriformes).Journal of anatomy · 2022Article
- X-ray microtomography imaging of craniofacial hard tissues in selected reptile species with different types of dentition.GigaScience · 2022Article
- Multiple evolutionary origins and losses of tooth complexity in squamates.Nature communications · 2021Article
- Plicidentine and the repeated origins of snake venom fangs.Proceedings. Biological sciences · 2021Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Snake fangs are an iconic exemplar of a complex adaptation, but despite striking developmental and morphological similarities, they probably evolved independently in several lineages of venomous snakes. How snakes could, uniquely among vertebrates, repeatedly evolve their complex venom delivery apparatus is an intriguing question. Here we shed light on the repeated evolution of snake venom fangs using histology, high-resolution computed tomography (microCT) and biomechanical modelling. Our examination of venomous and non-venomous species reveals that most snakes have dentine infoldings at the bases of their teeth, known as plicidentine, and that in venomous species, one of these infoldings was repurposed to form a longitudinal groove for venom delivery. Like plicidentine, venom grooves originate from infoldings of the developing dental epithelium prior to the formation of the tooth hard tissues. Derivation of the venom groove from a large plicidentine fold that develops early in tooth ontogeny reveals how snake venom fangs could originate repeatedly through the co-option of a pre-existing dental feature even without close association to a venom duct. We also show that, contrary to previous assumptions, dentine infoldings do not improve compression or bending resistance of snake teeth during biting; plicidentine may instead have a role in tooth attachment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.