Evidence map›Paper›PMID 34375259›Full record

ArticleThe Science of the total environment2021

Lessons learned from SARS-CoV-2 measurements in wastewater.

Mark E Sharkey, Naresh Kumar, Alejandro M A Mantero, Kristina M Babler, Melinda M Boone, Yoslayma Cardentey, Elena M Cortizas, George S Grills, James Herrin, Jenny M Kemper and 21 more

Abstract read
In one paragraph

Article in The Science of the total environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Optimized Aluminum Hydroxide Adsorption-Precipitation for Improved Viral Detection in Wastewater.International journal of environmental research and public health · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Mark E SharkeyDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Naresh KumarDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Alejandro M A ManteroDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Kristina M BablerDepartment of Marine Biology and Ecology, University of Miami, Key Biscayne, FL, USA.
Melinda M BooneSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Yoslayma CardenteySylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Elena M CortizasSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
George S GrillsSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
James HerrinLuminUltra Technologies, Miami Lakes, FL, USA.
Jenny M KemperSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Richard KenneyHousing Operations & Facilities, University of Miami, Coral Gables, FL, USA.
Erin KobetzDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Jennifer LaineEnvironmental Health and Safety, University of Miami Miller School of Medicine, Miami, FL, USA.
Walter E LamarFacilities Safety & Compliance, University of Miami Miller School of Medicine, Miami, FL, USA.
Christopher C MaderInstitute for Data Science & Computing, University of Miami, Coral Gables, FL, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY, USA.
Anda Z QuinteroLuminUltra Technologies, Miami Lakes, FL, USA.
Brian D RedingEnvironmental Health and Safety, University of Miami Miller School of Medicine, Miami, FL, USA.
Matthew A RocaDepartment of Civil, Architectural, and Environmental Engineering, University of Miami, Coral Gables, FL, USA.
Krista RyonDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY, USA.
Natasha Schaefer SolleDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Stephan C SchürerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA; Institute for Data Science & Computing, University of Miami, Coral Gables, FL, USA; Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicines, Miami, FL, USA.
Bhavarth ShuklaDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Mario StevensonDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Thomas StoneDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
John J TallonFacilities and Operations, University of Miami, Coral Gables, FL, USA.
Sreeharsha S VenkatapuramInstitute for Data Science & Computing, University of Miami, Coral Gables, FL, USA.
Dusica VidovicDepartment of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicines, Miami, FL, USA.
Sion L WilliamsSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Benjamin YoungDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY, USA.
Helena M Solo-GabrieleDepartment of Civil, Architectural, and Environmental Engineering, University of Miami, Coral Gables, FL, USA. Electronic address: hmsolo@miami.edu.

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Supplement for MINI point-of-use deviceU01DA053941 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI MASON, CHRISTOPHER EDWARD, SCHURER, STEPHAN C · 2021 to 2022
$5.2M
NCATS NIH HHS UL1 TR002736NIAID NIH HHS P30 AI073961NIDA NIH HHS U01 DA053941
6 · The paper itself

Abstract

Standardized protocols for wastewater-based surveillance (WBS) for the RNA of SARS-CoV-2, the virus responsible for the current COVID-19 pandemic, are being developed and refined worldwide for early detection of disease outbreaks. We report here on lessons learned from establishing a WBS program for SARS-CoV-2 integrated with a human surveillance program for COVID-19. We have established WBS at three campuses of a university, including student residential dormitories and a hospital that treats COVID-19 patients. Lessons learned from this WBS program address the variability of water quality, new detection technologies, the range of detectable viral loads in wastewater, and the predictive value of integrating environmental and human surveillance data. Data from our WBS program indicated that water quality was statistically different between sewer sampling sites, with more variability observed in wastewater coming from individual buildings compared to clusters of buildings. A new detection technology was developed based upon the use of a novel polymerase called V2G. Detectable levels of SARS-CoV-2 in wastewater varied from 10

Indexed as

COVID-19SARS-CoV-2HumansPandemicsRNA, ViralWastewaterRNA, ViralWastewaterConcentrationDetectionSamplingSARS-CoV-2WastewaterWastewater based surveillance

Identifiers

PMID34375259
PMCPMC8294117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.