SynthesisSports medicine (Auckland, N.Z.)2021
Ghrelin Response to Acute and Chronic Exercise: Insights and Implications from a Systematic Review of the Literature.
Synthesis in Sports medicine (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Systematic Review: Does Exercise Training Influence Ghrelin Levels?International journal of molecular sciences · 2025Pooled it
- Effect of long-term exercise on circulating ghrelin in overweight and obese individuals: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- The acute effects of moderate-intensity continuous or high-intensity interval exercise on appetite and appetite-related hormones in South Asian and white European adults with non-diabetic hyperglycaemia.European journal of clinical nutrition · 2025Trial
- Trial
- Aerobic exercise elevates perceived appetite but does not modify energy intake over a 3-day postexercise period: A pilot study.Physiological reports · 2024Trial
- Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?Experimental biology and medicine (Maywood, N.J.) · 2022Trial
- Effects of a 12-Week Diet versus Diet plus Aerobic and Resistance Exercise Program on Acylated and Desacylated Ghrelin, and Ghrelin O-Acyltransferase in Adolescent Girls with Obesity.International journal of environmental research and public health · 2022Trial
- Sex-specific changes in appetite and energy intake in response to chronic resistance training in rats.Physiological reports · 2026Article
- Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice.EBioMedicine · 2026Article
- Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.Journal of cachexia, sarcopenia and muscle · 2025Article
- Influence of 8-week endurance training on resting energy expenditure and body composition in women.Physiological reports · 2025Article
- Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025Review
- Age-Related Differences in the Appetite-Regulating Hormone Response to Exercise.Current developments in nutrition · 2025Article
- Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.The British journal of nutrition · 2025Article
- Hormonal Imbalance in Obesity and Arthritis: Points of Contact.Current rheumatology reviews · 2025Review
- Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis.Nutrition and cancer · 2025Article
- Impact of Resistance and Endurance Training on Ghrelin and Plasma Leptin Levels in Overweight and Obese Subjects.International journal of molecular sciences · 2024Review
- Examining the Potential Applicability of Orexigenic and Anorexigenic Peptides in Veterinary Medicine for the Management of Obesity in Companion Animals.Current issues in molecular biology · 2024Review
- Changes in ghrelin, GLP-1, and PYY levels after diet and exercise in obese individuals.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Ameliorative effects of aerobic training in girls with precocious puberty: role of leptin and ghrelin.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGhrelin is a peptide hormone predominantly produced by the stomach. It exerts a wide range of functions including stimulating growth hormone release and regulating appetite, food intake, and glucose and lipid metabolism. Since physical exercise affects all these aspects, a particular interest is accorded to the relationship between ghrelin and exercise. This systematic review aimed to summarize the current available data on the topic for a better understanding of the relationship.
methodsAn extensive computerized search was performed in the PubMed and SPORTDiscus databases for retrieving relevant articles. The search contained the following keywords: ghrelin, appetite-related peptides, gastrointestinal peptides, gastrointestinal hormones, exercise, acute exercise, chronic exercise, training, and physical activity. Studies investigating the effects of acute/chronic exercise on circulating forms of ghrelin were included.
resultsThe initial search identified 840 articles. After screening, 80 articles were included. Despite a heterogeneity of studies and a variability of the findings, the review suggests that acute exercise suppresses acyl ghrelin production regardless of the participants and the exercise characteristics. Long- and very long-term exercise training programs mostly resulted in increased total and des-acyl ghrelin production. The increase is more noticeable in overweight/obese individuals, and is most likely due to weight loss resulting from the training program.
conclusionThe review suggests that exercise may impact ghrelin production. While the precise mechanisms are unclear, the effects are likely due to blood flow redistribution and weight loss for acute and chronic exercise, respectively. These changes are expected to be metabolically beneficial. Further research is needed for a better understanding of the relationship between ghrelin and exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.