Evidence map›Paper›PMID 34374945›Full record

ReviewAnnals of biomedical engineering2021

High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.

Vismaya S Bachu, Jayanidhi Kedda, Ian Suk, Jordan J Green, Betty Tyler

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 3 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 3 syntheses or guidelines pooled it, 262 citations in OpenAlex.

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  20. Overview of Diagnostic Ultrasound Safety: Review for Research and Institutional Review Boards.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Review

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vismaya S BachuDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jayanidhi KeddaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Ian SukDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jordan J GreenDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Betty TylerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. btyler@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Gene Delivery Nanoparticles to Treat GlioblastomaR01CA228133 · NCI · JOHNS HOPKINS UNIVERSITY · PI GREEN, JORDAN · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA228133NIH HHS R01CA228133
6 · The paper itself

Abstract

High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful modality in the treatment of cancer and other diseases. Although traditional use of ultrasound at lower frequencies has primarily been for diagnostic imaging purposes, the development of HIFU has allowed this particular modality to expand into therapeutic use. This non-invasive and acoustic method involves the use of a piezoelectric transducer to deliver high-energy pulses in a spatially coordinated manner, while minimizing damage to tissue outside the target area. This review describes the history of the development of diagnostic and therapeutic ultrasound and explores the biomedical applications utilizing HIFU technology including thermally ablative treatment, therapeutic delivery mechanisms, and neuromodulatory phenomena. The application of HIFU across various tumor types in multiple organ systems is explored in depth, with particular attention to successful models of HIFU in the treatment of various medical conditions. Basic mechanisms, preclinical models, previous clinical use, and ongoing clinical trials are comparatively discussed. Recent advances in HIFU across multiple medical fields reveal the growing importance of this biomedical technology for the care of patients and for the development of possible pathways for the future use of HIFU as a commonplace treatment modality.

Indexed as

Extracorporeal Shockwave TherapyAnimalsCentral Nervous System DiseasesDrug Delivery SystemsHumansNeoplasmsUltrasonographyAblationDrug deliveryFocused ultrasoundNeuromodulationSonoporation

Identifiers

PMID34374945
PMCPMC8608284
OpenAlexW3187668469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.