Evidence map›Paper›PMID 34374937›Full record

ArticleClinical and experimental medicine2022

CD19 + CD21

Erin M Wilfong, Katherine N Vowell, Kaitlyn E Bunn, Elise Rizzi, Narender Annapureddy, Rosemarie B Dudenhofer, April Barnado, Rachel H Bonami, Joyce E Johnson, Leslie J Crofford and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Multiparameter analysis of human B lymphocytes identifies heterogeneous CD19Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Erin M WilfongDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-6584-1578
Katherine N VowellDivision of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kaitlyn E BunnDeparment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Elise RizziDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Narender AnnapureddyDivision of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Rosemarie B DudenhoferDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
April BarnadoDivision of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Rachel H BonamiDivision of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Joyce E JohnsonDeparment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Leslie J CroffordDivision of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Peggy L KendallDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. peggy.kendall@wustl.edu.
Vanderbilt University Medical Center · USVanderbilt University · USWashington University in St. Louis · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
Interdisciplinary Training in Rheumatic DiseasesT32AR059039 · NIAMS · VANDERBILT UNIVERSITY · PI Tracy Minan Frech, AMY S MAJOR · 2010 to 2026
$4.3M
Bruton's Tyrosine Kinase and Immune Tolerance in Type 1 DiabetesR01DK084246 · NIDDK · WASHINGTON UNIVERSITY · PI KENDALL, PEGGY L · 2011 to 2019
$3.2M
Using the electronic health record to risk-stratify patients with systemic lupus erythematosusK08AR072757 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARNADO, APRIL LYNN · 2018 to 2022
$817k
B Lymphocytes in Autoimmune DiseaseI01BX002882 · VA · VETERANS HEALTH ADMINISTRATION · PI KENDALL, PEGGY L · 2016 to 2025
–
BLRD VA I01 BX002882NCATS NIH HHS KL2 TR002245NCATS NIH HHS KL2TR002245NCATS NIH HHS UL1 TR000445NHLBI NIH HHS T32 HL087738NHLBI NIH HHS T32HL087738NIAMS NIH HHS K08 AR072757NIAMS NIH HHS K08AR072757NIAMS NIH HHS T32AR0590139NIAMS NIH HHS T32 AR059039NICHD NIH HHS K12 HD043483NIDDK NIH HHS R01 DK084246NIDDK NIH HHS R01DK084246U.S. Department of Veterans Affairs BX002882
6 · The paper itself

Abstract

Interstitial lung disease (ILD) represents a significant cause of morbidity and mortality in systemic sclerosis (SSc). The purpose of this study was to examine recirculating lymphocytes from SSc patients for potential biomarkers of interstitial lung disease (ILD). Peripheral blood mononuclear cells (PBMCs) were isolated from patients with SSc and healthy controls enrolled in the Vanderbilt University Myositis and Scleroderma Treatment Initiative Center cohort between 9/2017-6/2019. Clinical phenotyping was performed by chart abstraction. Immunophenotyping was performed using both mass cytometry and fluorescence cytometry combined with t-distributed stochastic neighbor embedding analysis and traditional biaxial gating. This study included 34 patients with SSc-ILD, 14 patients without SSc-ILD, and 25 healthy controls. CD21

Indexed as

Lung Diseases, InterstitialScleroderma, SystemicAdaptor Proteins, Signal TransducingBiomarkersHumansLeukocytes, MononuclearLungReceptors, Complement 3dAdaptor Proteins, Signal TransducingBiomarkersReceptors, Complement 3dCD21lo B cellsInterstitial lung diseaseMass cytometrySystemic sclerosis

Identifiers

PMID34374937
PMCPMC8828801
OpenAlexW3188083854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.