Evidence map›Paper›PMID 34374805›Full record

ArticlePsychopharmacology2021

Human umbilical cord mesenchymal stem cells ameliorate depression by regulating Jmjd3 and microglia polarization in myocardial infarction mice.

Youyang Zhang, Xinan Wang, Yuhang Li, Ruiping Liu, Jiangqi Pan, Xiane Tang, Shuifen Sun, Jie Liu, Wenlin Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. The Therapeutic Potential of Stem Cells in Depression.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Youyang ZhangDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xinan WangDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Rd, Putuo District, Shanghai, 200092, China.
Yuhang LiDepartment of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Ruiping LiuDepartment of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jiangqi PanDepartment of Cardiology, Gongli Hospital, Navy Military Medical University, Shanghai, China.
Xiane TangDepartment of Clinical Medicine, School of Medicine, Hubei University for Nationalities, Enshi, China.
Shuifen SunRegenerative Medicine Research Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Jie LiuRegenerative Medicine Research Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Wenlin MaDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. mawenlin@tongji.edu.cn.ORCID http://orcid.org/0000-0002-1591-7028
Tongji University · CNKunming University of Science and Technology · CNHubei University for Nationalities · CNSecond Military Medical University · CN

Funding

National Key R&D Program of China 2018YFC1314700National Natural Science Foundation of China 82060242Shanghai Municipal Health Commission Foundation of Shanghai 2019SY026Shanghai Municipal Health Commission Foundation of Shanghai 2019ZB0202SShanghai Tongji Hospital ITJ[ZD]1809
6 · The paper itself

Abstract

rationaleMicroglia regulate the inflammation of the central nervous system and play a crucial role in the pathogenesis of depression. Moreover, Jmjd3 is involved in microglia polarization. Mounting studies reported the beneficial effects of human umbilical cord mesenchymal stem cells (HUC-MSCs) on myocardial infarction (MI), Unfortunately, its effects on MI-induced depression and its underlying mechanisms remain unclear.

objectivesWe aimed to investigate the antidepressant effects of HUC-MSCs and their impacts on microglia polarization.

methodsIn the current study, the MI model was established by ligating the left anterior descending coronary artery. Mice were injected with HUC-MSCs or PBS through the tail vein 1week after the surgery. The sucrose preference test (SPT), tail suspension test (TST), and forced swim test (FST) were performed to evaluate depression-like behavior. Cardiac function and myocardial fibrosis were evaluated at the end of the experiments. Immunofluorescence, Western blot, ELISA, and qRT-PCR were used to detect the levels of Jmjd3 and microglia-related markers and inflammatory factors.

resultsHUC-MSC treatment significantly improved cardiac function, reduced the area of myocardial fibrosis, and alleviated depression-like behaviors induced by MI. HUC-MSCs inhibited the expression of Jmjd3 and promoted the switch of microglia in the prefrontal cortex, hypothalamus, and hippocampus from M1 to M2, thereby decreased the level of pro-inflammatory factors.

conclusionHUC-MSCs have cardioprotective and potential anti-depressive effects induced by MI related to the inflammation improved by regulating Jmjd3 and microglial polarization.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyocardial InfarctionAnimalsDepressionHumansMiceMicrogliaUmbilical CordDepressionHUC-MSCsInflammationJmjd3MicrogliaMyocardial infarction

Identifiers

PMID34374805
OpenAlexW3188108620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.