Evidence map›Paper›PMID 34374669›Full record

ReviewCurrent opinion in allergy and clinical immunology2021

Basophil activation test in food allergy: is it ready for real-time?

Tarun Keswani, Sarita U Patil

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559319 (Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06559319 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation Of the Basophil Activation Test in Child Egg Allergy Diagnosis

TypeobservationalSponsorXia PengRan2024 to 2027Enrolled174ConditionsFood AllergyArmsblood sampling
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Buckwheat Allergy in Asia.Current allergy and asthma reports · 2024
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tarun KeswaniCenter for Immunological and Inflammatory Diseases, Department of Medicine.
Sarita U PatilCenter for Immunological and Inflammatory Diseases, Department of Medicine.
Massachusetts General Hospital · US

Funding

Structural and functional characterization of protective antibodies induced in peanut oral immunotherapyR01AI155630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Sarita U Patil · 2021 to 2026
$3.1M
Role of Memory IgG B Cells in the Development of Tolerance in Food AllergyR21AI159732 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PATIL, SARITA U · 2021 to 2022
$462k
NIAID NIH HHS R01 AI155630NIAID NIH HHS R21 AI159732
6 · The paper itself

Abstract

purpose of reviewUtilization of basophil activation in the diagnosis and monitoring of food allergy has gained increasing recognition. An ex-vivo functional assay, basophil activation reflects clinical reactivity, thereby providing clinically relevant insights. Moreover, as a biomarker of reactivity and tolerance, basophil activation testing (BAT) may provide a useful tool for management of food allergies. Despite its utility, significant limitations of BAT have prevented widespread use. Addressing these limitations will increase the future application and adoption of BAT in food allergy. RECENT

findingsA number of clinical trials in the past few years have demonstrated the use of BAT in the diagnosis and treatment of food allergy. Specifically, BAT has been found to be a biomarker of tolerance. SUMMARY: Basophil activation testing is an effective biomarker for diagnosis and monitoring of food allergy.

Indexed as

BasophilsFood HypersensitivityAllergensBiomarkersHumansImmune ToleranceAllergensBiomarkers

Identifiers

PMID34374669
PMCPMC8629129
OpenAlexW3188553145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.