Evidence map›Paper›PMID 34374594›Full record

ArticleRadiology2021

Three-dimensional MR Elastography Depicts Liver Inflammation, Fibrosis, and Portal Hypertension in Chronic Hepatitis B or C.

Yu Shi, Ya-Fei Qi, Gong-Yu Lan, Qijun Wu, Bing Ma, Xian-Yi Zhang, Ruo-Yun Ji, Yu-Jia Ma, Yang Hong

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05475015 recruitingnot on this mapstarted 2022, after this paper: background citation

Three-dimensional MR Elastography for Assessing Cirrhosis and Portal Hypertension (CHESS2206): A Prospective Multicenter Study

TypeobservationalSponsorShengjing HospitalRan2022 to 2026Enrolled150ConditionsCirrhosis, Liver, Portal Hypertension, Advanced Chronic Liver DiseaseArms3D-MRE, HVPG
NCT06205992 recruitingnot on this mapstarted 2022, after this paper: background citation

Three-dimensional MR Elastography and Two-dimensional MR Elastography for Assessing Cirrhosis and Portal Hypertension：A Prospective Multicenter Study

TypeobservationalSponsorShengjing HospitalRan2022 to 2026Enrolled100ConditionsCirrhosis, Liver Portal HypertensionArms3D-MRE, HVPG, 2D-MRE
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Imaging Evaluation for Steatotic Liver Disease.Korean journal of radiology · 2026
    Review
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. MASLD: What We Have Learned and Where We Need to Go-A Call to Action.Radiographics : a review publication of the Radiological Society of North America, Inc · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu ShiFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).ORCID 0000-0003-1940-0074
Ya-Fei QiFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Gong-Yu LanFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Qijun WuFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Bing MaFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Xian-Yi ZhangFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Ruo-Yun JiFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Yu-Jia MaFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).
Yang HongFrom the Departments of Radiology (Y.S., G.Y.L., X.Y.Z., R.Y.J., Y.J.M.), Pathology (Y.F.Q.), Clinical Epidemiology (Q.W.), and Neurosurgery (Y.H.), Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, People's Republic of China; and Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, and Center of Evidence Based Medicine, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China (B.M.).ORCID 0000-0001-7219-3241
China Medical University · CN

Funding

Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R37 EB001981
6 · The paper itself

Abstract

Background The value of measuring mechanical properties to categorize various pathophysiologic states of the liver is as yet undetermined in chronic hepatitis B (CHB) or C (CHC). Purpose To evaluate multiparametric three-dimensional (3D) MR elastography as a means of detecting early necroinflammation, distinguishing necroinflammation from fibrosis, and gauging the severity of portal hypertension (PH) in CHB or CHC. Materials and Methods From January 2015 to September 2019, participants with CHB or CHC were prospectively enrolled from a single institution and were divided into two groups: those with liver biopsy and no evidence of PH (group 1) and those with PH and a hepatic venous pressure gradient (HVPG) measurement (group 2). For group 3, healthy volunteers were separately recruited from a nearby community. Multiple viscoelastic parameters (shear stiffness [SS], storage modulus, loss modulus, and damping ratio [DR]) were determined at 3D MR elastography at 60 Hz, and multivariable logistic or linear regression analysis was used to assess associations of mechanical parameters with histologic scores and HVPG. Results A total of 155 participants (median age, 41 years [interquartile range, 32-48 years]; 85 women) were in group 1 (training set:

Indexed as

AdultCross-Sectional StudiesElasticity Imaging TechniquesFemaleHepatitis B, ChronicHepatitis C, ChronicHumansHypertension, PortalImaging, Three-DimensionalInflammationLiverLiver CirrhosisMaleMiddle AgedProspective Studies

Identifiers

PMID34374594
PMCPMC8475654
OpenAlexW3187313969

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.