Evidence map›Paper›PMID 34374563›Full record

ArticlemSystems2021

Population Genomics of

Sruti DebRoy, Misu Sanson, Brittany Shah, Shirjana Regmi, Luis Alberto Vega, Chioma Odo, Pranoti Sahasrabhojane, Allison McGeer, Gregory J Tyrrell, Nahuel Fittipaldi and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Regulation of erm(T) MLSnpj antimicrobials and resistance · 2024
    Article
  4. Article
  5. Molecular characterization ofMicrobial genomics · 2024
    Article
  6. EmergentInfection and immunity · 2024
    Article
  7. Article
  8. NovelMicrobial genomics · 2023
    Article
  9. Invasive group A streptococcal disease surveillance in Canada, 2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sruti DebRoyDepartment of Infectious Diseases Infection Control and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.
Misu SansonDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.
Brittany ShahDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.
Shirjana RegmiDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.
Luis Alberto VegaDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.
Chioma OdoDepartment of Infectious Diseases Infection Control and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.
Pranoti SahasrabhojaneDepartment of Infectious Diseases Infection Control and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.
Allison McGeerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Gregory J TyrrellAlberta Public Health Laboratories, Public Health-Alberta Health Services, Edmonton, Alberta, Canada.
Nahuel FittipaldiDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Samuel A ShelburneDepartment of Infectious Diseases Infection Control and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA.
Anthony R FloresDivision of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USUniversity of Toronto · CAAlberta Health Services · CA

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
Defining novel mechanisms of clonal emergence in Group A StreptococcusR21AI159059 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLORES, ANTHONY RICHARD, SHELBURNE, SAMUEL A · 2021 to 2022
$453k
Impact of a novel emm-enn gene fusion event on epidemic behavior of group A streptococcusR21AI142126 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLORES, ANTHONY RICHARD, SHELBURNE, SAMUEL A · 2019 to 2020
$447k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI141349HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI142126NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342NIAID NIH HHS R21 AI142126NIAID NIH HHS R21 AI159059NIAID NIH HHS T32 AI141349
6 · The paper itself

Abstract

Clonal replacement is a major driver for changes in bacterial disease epidemiology. Recently, it has been proposed that episodic emergence of novel, hypervirulent clones of group A Streptococcus (GAS) results from acquisition of a 36-kb DNA region leading to increased expression of the cytotoxins Nga (NADase) and SLO (streptolysin O). We previously described a gene fusion event involving the gene encoding the GAS M protein (

Indexed as

evolutionexotoxingenomicsgroup A StreptococcusM typepopulation geneticsvirulence

Identifiers

PMID34374563
PMCPMC8409732
OpenAlexW3189007228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.