Evidence map›Paper›PMID 34374560›Full record

ArticlemSystems2021

Recurrent Vulvovaginal Candidiasis: a Dynamic Interkingdom Biofilm Disease of

Emily McKloud, Christopher Delaney, Leighann Sherry, Ryan Kean, Shanice Williams, Rebecca Metcalfe, Rachael Thomas, Riina Richardson, Konstantinos Gerasimidis, Christopher J Nile and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Contribution ofFrontiers in cellular and infection microbiology · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. State-of-the-Art Review: Managing Vulvovaginal Candidiasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  8. Non-Frontiers in microbiology · 2026
    Review
  9. Inhibitory effect ofFrontiers in cellular and infection microbiology · 2026
    Article
  10. Evaluation ofFrontiers in microbiology · 2026
    Article
  11. VaginalFrontiers in microbiology · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Impact of Biofilm Formation by VaginalJournal of fungi (Basel, Switzerland) · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Emily McKloud *School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Christopher Delaney *School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Leighann SherrySchool of Life Sciences, Glasgow, UK.
Ryan KeanDepartment of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Shanice WilliamsSchool of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Rebecca MetcalfeSandyford Sexual Health Service, NHS Greater Glasgow and Clydegrid.413301.4, Glasgow, UK.
Rachael ThomasSandyford Sexual Health Service, NHS Greater Glasgow and Clydegrid.413301.4, Glasgow, UK.
Riina RichardsonDivision of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchestergrid.5379.8, Manchester, UK.
Konstantinos GerasimidisSchool of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Christopher J NileSchool of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK.
Craig WilliamsSchool of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
Gordon RamageSchool of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK.
NHS Greater Glasgow and Clyde · GBGlasgow Caledonian University · GBGlasgow Life · GBUniversity of Manchester · GB

Funding

UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P504567/1
6 · The paper itself

Abstract

Despite the strikingly high worldwide prevalence of vulvovaginal candidiasis (VVC), treatment options for recurrent VVC (RVVC) remain limited, with many women experiencing failed clinical treatment with frontline azoles. Further, the cause of onset and recurrence of disease is largely unknown, with few studies identifying potential mechanisms of treatment failure. This study aimed to assess a panel of clinical samples from healthy women and those with RVVC to investigate the influence of

Indexed as

antifungal resistancebiofilmCandidaclinicalinterkingdomLactobacillusmicrobiomevulvovaginal candidiasis

Identifiers

PMID34374560
PMCPMC8407231
OpenAlexW3191494272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.