Evidence map›Paper›PMID 34374542›Full record

ArticleThe journal of physical chemistry letters2021

Curvature of the Retroviral Capsid Assembly Is Modulated by a Molecular Switch.

Tyrone Thames, Alexander J Bryer, Xin Qiao, Jaekyun Jeon, Ryan Weed, Kaylie Janicki, Bingwen Hu, Peter L Gor'kov, Ivan Hung, Zhehong Gan and 2 more

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Molecular basis for curvature formation in SepF polymerization.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Understanding Virus Structure and Dynamics through Molecular Simulations.Journal of chemical theory and computation · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Tyrone ThamesDepartment of Physics, University of Central Florida, Orlando, Florida 32816, United States.
Alexander J BryerDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Xin QiaoDepartment of Physics, University of Central Florida, Orlando, Florida 32816, United States.
Jaekyun JeonLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland 20892, United States.
Ryan WeedDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.
Kaylie JanickiDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.
Bingwen HuState Key Laboratory of Precision Spectroscopy, Shanghai Key Laboratory of Magnetic Resonance, Institute of Functional Materials, School of Physics and Materials Science, East China Normal University, Shanghai 200062, PR China.ORCID https://orcid.org/0000-0003-0694-0178
Peter L Gor'kovNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, United States.
Ivan HungNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, United States.ORCID https://orcid.org/0000-0001-8916-739X
Zhehong GanNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, United States.ORCID https://orcid.org/0000-0002-9855-5113
Juan R PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID https://orcid.org/0000-0003-1171-6816
Bo ChenDepartment of Physics, University of Central Florida, Orlando, Florida 32816, United States.ORCID https://orcid.org/0000-0001-5589-2075
University of Central Florida · USFlorida State University · USUniversity of Delaware · USEast China Normal University · CNNational Institutes of Health · US

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Technology Development 2: MAS NMR and dynamic nuclear polarization for HIV-1 structural biologyP50AI150481 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M. · 2019 to 2021
$14.1M
Biochemistry and Biophysics of Capsid Function in HIV-1 InfectionR56AI076121 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AIKEN, CHRISTOPHER R · 2019 to 2019
$472k
NIAID NIH HHS P50 AI150481NIAID NIH HHS R56 AI076121NIGMS NIH HHS P20 GM104316
6 · The paper itself

Abstract

During the maturation step, the retroviral capsid proteins (CAs) assemble into polymorphic capsids. Their acute curvature is largely determined by 12 pentamers inserted into the hexameric lattice. However, how the CA switches its conformation to control assembly curvature remains unclear. We report the high-resolution structural model of the Rous sarcoma virus (RSV) CA

Indexed as

CapsidCapsid ProteinsMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularPliabilityProtein ConformationProtein DomainsRous sarcoma virusCapsid Proteins

Identifiers

PMID34374542
PMCPMC9083439
OpenAlexW3188249522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.