Evidence map›Paper›PMID 34374471›Full record

ArticleMagnetic resonance in medicine2022

Clinical translation of hyperpolarized

Hecong Qin, Shuyu Tang, Andrew M Riselli, Robert A Bok, Romelyn Delos Santos, Mark van Criekinge, Jeremy W Gordon, Rahul Aggarwal, Rui Chen, Gregory Goddard and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  3. Review
  4. Article
  5. Across-cities transportableNature communications · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Three-dimensional high-resolution TMagnetic resonance in medicine · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Data Format Standardization and DICOM Integration for HyperpolarizedJournal of imaging informatics in medicine · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Hecong QinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-2618-8366
Shuyu TangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-9911-482X
Andrew M RiselliDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-0714-5726
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Mark van CriekingeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-2760-4886
Rahul AggarwalDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Rui ChenGeneral Electric Healthcare, Milwaukee, Wisconsin, USA.
Gregory GoddardGeneral Electric Research, Niskayuna, New York, USA.
Chunxin Tracy ZhangGeneral Electric Research, Niskayuna, New York, USA.
Albert ChenGeneral Electric Healthcare, Milwaukee, Wisconsin, USA.
Galen ReedGeneral Electric Healthcare, Milwaukee, Wisconsin, USA.
Daniel M RuscittoGeneral Electric Healthcare, Milwaukee, Wisconsin, USA.
James SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Renuka SriramDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-3505-2479
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-5795-8699
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-3544-5339
University of California, San Francisco · USGeneral Electric (United States) · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Preclinical imaging characterization and resource development of PDX SCNC prostate cancer murine modelsU24CA253377 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, PEEHL, DONNA M. · 2020 to 2024
$3.4M
CLINICAL TRANSLATION OF HYPERPOLARIZED 13C-UREA FOR CANCER MR MOLECULAR IMAGINGR01CA214554 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, RUSCITTO, DANIEL MARTIN · 2017 to 2021
$3.3M
NCI NIH HHS R01 CA214554NCI NIH HHS U24 CA253377NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

purposeThe combined hyperpolarized (HP)

methodsA co-polarization system was developed where [1-

resultsThe combined PA/urea probe has a glass-formation ability similar to neat PA and can generate nearly 40% liquid-state

conclusionThe reported technical development and translational studies will lead to the first-in-human dual-agent HP MRI study and mark the clinical translation of the first HP

Indexed as

Pyruvic AcidUreaCarbon IsotopesHumansLactic AcidMagnetic Resonance ImagingPerfusion ImagingCarbon IsotopesLactic AcidPyruvic AcidUreaclinical translationhyperpolarizationmetabolismperfusionpyruvateurea

Identifiers

PMID34374471
PMCPMC8616838
OpenAlexW3191234325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.