ArticleThe Journal of infectious diseases2021
The Gut Microbiome of Healthy Vietnamese Adults and Children Is a Major Reservoir for Resistance Genes Against Critical Antimicrobials.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Metagenomic profiling reveals shared resistome signatures between humans and pigs in Vietnamese smallholder farms.npj antimicrobials and resistance · 2026Article
- Understanding the bacteriome, phageome and phage-associated bacteriome in healthy Vietnamese children under two years of age.Archives of microbiology · 2026Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- The role of the gut microbiome in antibiotic-driven antimicrobial resistance.Frontiers in microbiology · 2026Review
- Metagenomic identification of disease-causingMicrobial genomics · 2025Article
- Understanding the influence of the microbiome on childhood infections.Expert review of anti-infective therapy · 2024Review
- The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.Nature communications · 2024Observational
- The impact of antibiotics on the gut microbiota of children recovering from watery diarrhoea.npj antimicrobials and resistance · 2024Article
- Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.NPJ biofilms and microbiomes · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
Antimicrobials are a key group of therapeutic agents. Given the animal/human population density and high antimicrobial consumption rate in Southeast Asia, the region is a focal area for monitoring antimicrobial resistance (AMR). Hypothesizing that the gastrointestinal tract of healthy individuals in Vietnam is a major source of AMR genes that may be transferred to pathogens, we performed shotgun metagenomic sequencing on fecal samples from 42 healthy Vietnamese people (21 children and 21 adults). We compared their microbiome profiles by age group and determined the composition of AMR genes. An analysis of the taxonomic profiles in the gut microbiome showed a clear differentiation by age, with young children (age <2 years) exhibiting a unique structure in comparison to adults and older children. We identified a total of 132 unique AMR genes, with macrolide, lincosamide, and streptogramin class resistance genes (ermB and lnuC) and tetracycline resistance genes being almost ubiquitous across the study population. Notably, samples from younger children were significantly associated with a greater number of AMR genes than other age groups, including key signature genes associated with AMR pathogens (eg, blaCTX-M, mphA). Our data suggest that the gut microbiome of those living in Vietnam, particularly young children, is a substantial reservoir of AMR genes, which can be transferred to circulating enteric pathogens. Our data support the generation of longitudinal cohort studies of those living in urban and rural areas of developing countries to understand the behavior of these AMR reservoirs and their role in generating multidrug-resistant and extensively drug-resistant pathogens.
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