ArticleEmerging topics in life sciences2021
Mitochondrial DNA in forensic use.
Article in Emerging topics in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric analysis of kinship analysis from 1960 to 2023: global trends and development.Frontiers in genetics · 2024Pooled it
- Pedigree-Based comparison of short-read and long-read sequencing for forensic mitochondrial genome analysis.International journal of legal medicine · 2026Article
- Review
- Review
- Molecular Age Estimation: Current Perspectives and Future Considerations.International journal of molecular sciences · 2026Review
- A multi-level overview of the hair decomposition process.International journal of legal medicine · 2025Review
- Optimization of a DNA extraction protocol from fingerprints for the analysis of nuclear STR and mitochondrial DNA genetic profiles.Forensic sciences research · 2025Article
- Quantitation of human mitochondrial DNA and whole mtGenomes sequencing of fingernail/hair shaft samples.Forensic sciences research · 2025Article
- Ethnogenetic analysis reveals the Bronze Age genetic affiliation of Yashkuns with West Eurasians.Scientific reports · 2024Article
- A brief clinical genetics review: stepwise diagnostic processes of a monogenic disorder-hypertriglyceridemia.Translational pediatrics · 2024Review
- Mitochondrial Control Region Database of Hungarian Fallow Deer (Animals : an open access journal from MDPI · 2024Article
- mtDNA analysis using Mitopore.Molecular therapy. Methods & clinical development · 2024Article
- Review
- Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation.International journal of molecular sciences · 2024Review
- Advancements and Applications of Preimplantation Genetic Testing in In Vitro Fertilization: A Comprehensive Review.Cureus · 2024Review
- Species Identification of Rehabilitated Critically Endangered Orangutans Through DNA Forensic: Implication for Conservation.Tropical life sciences research · 2024Article
- Law enforcement use of genetic genealogy databases in criminal investigations: Nomenclature, definition and scope.Forensic science international. Synergy · 2024Article
- Single cell genomics applications in forensic science: Current state and future directions.iScience · 2023Review
- Article
- The Revolution of Animal Genomics in Forensic Sciences.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic analysis of mitochondrial DNA (mtDNA) has always been a useful tool for forensic geneticists, mainly because of its ubiquitous presence in biological material, even in the absence of nuclear DNA. Sequencing, however, is not a skill that is part of the routine forensic analysis because of the relative rarity of requests, and the need for retention of necessary skill sets and associated accreditation issues. While standard Sanger sequencing may be relatively simple, many requests are made in the face of compromised biological samples. Newer technologies, provided through massively parallel sequencing (MPS), will increase the opportunity for scientists to include this tool in their routine, particularly for missing person investigations. MPS has also enabled a different approach to sequencing that can increase sensitivity in a more targeted approach. In these circumstances it is likely that only a laboratory that specialises in undertaking forensic mtDNA analysis will be able to take these difficult cases forward, more so because reviews of the literature have revealed significantly high levels of typing errors in publications reporting mtDNA sequences. The forensic community has set out important guidelines, not only in the practical aspects of analysis, but also in the interpretation of that sequence to ensure that accurate comparisons can be made. Analysis of low-level, compromised and ancient DNA is not easy, however, as contamination is extremely difficult to eliminate and circumstances leading to sequencing errors are all too easily introduced. These problems, and solutions, are discussed in the article in relation to several historic cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.