Evidence map›Paper›PMID 34374223›Full record

SynthesisESC heart failure2021

Prognostic factors of Takotsubo cardiomyopathy: a systematic review.

Xiaojia Lu, Pengyang Li, Catherine Teng, Peng Cai, Ling Jin, Chenlin Li, Qi Liu, Su Pan, Richard A F Dixon, Bin Wang

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. New insights into takotsubo syndrome: results from a multicenter cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  3. A novel parameter for risk stratification in patients with takotsubo syndrome.American heart journal plus : cardiology research and practice · 2026
    Article
  4. Incidence of ischemic stroke in Takotsubo cardiomyopathy patients: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Takotsubo syndrome linked to paroxysmal sympathetic hyperactivity as a postoperative complication after brain tumor removal: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Xiaojia LuDepartment of Cardiology, the First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, 515041, China.
Pengyang LiDivision of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Catherine TengDepartment of Medicine, Yale New Haven Health Greenwich Hospital, Greenwich, CT, USA.
Peng CaiDepartment of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USA.
Ling JinDepartment of Medicine, Metrowest Medical Center, Framingham, MA, USA.
Chenlin LiDepartment of Cardiology, the First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, 515041, China.
Qi LiuWafic Said Molecular Cardiology Research Laboratory, Texas Heart Institute, Houston, TX, USA.
Su PanWafic Said Molecular Cardiology Research Laboratory, Texas Heart Institute, Houston, TX, USA.
Richard A F DixonWafic Said Molecular Cardiology Research Laboratory, Texas Heart Institute, Houston, TX, USA.
Bin WangDepartment of Cardiology, the First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, 515041, China.
Houston Methodist · USShantou University · CNGreenwich Hospital · USMetroWest Medical Center · USVirginia Commonwealth University · USWorcester Polytechnic Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Takotsubo cardiomyopathy (TCM), characterized by reversible ventricular dysfunction, has similar mortality to acute coronary syndrome. With the growing interest in the diagnosis of and interventions for TCM, many risk factors had been found to affect the prognosis of TCM patients, such as age, sex, and pre-existing diseases. Because of the incomplete understanding of the pathophysiologic mechanism in TCM, evidence-based medical therapy for this condition is lacking. Early intervention on risk factors may improve the outcomes of TCM. In this review, we sought to provide up-to-date evidence on risk factors and medical therapies that affect TCM outcome. We found that male sex, physical triggers, and certain comorbidities such as chronic kidney disease, malignant disease, higher body mass index, sepsis, chronic obstructive pulmonary disease, and anaemia were associated with poor TCM prognosis. In contrast, race, hyperlipidaemia, diabetes mellitus, and mood disorders were not clearly associated with TCM prognosis. We also reviewed the effect of medical therapies on TCM outcome, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers, calcium channel blockers, and statins. The evidence that these medications confer a survival benefit on TCM patients is limited. Understanding these prognostic factors could help develop risk-stratification tools for TCM and establish effective prevention and interventions for this not-so-benign condition. Further multicentre clinical studies with large samples and meta-analyses of findings from previous studies are needed to address the inconsistent findings among the many potential risk factors for TCM.

Indexed as

Takotsubo CardiomyopathyBody Mass IndexComorbidityHumansMalePrognosisRisk FactorsPrognosisRisk factorsTakotsubo cardiomyopathyTreatment

Identifiers

PMID34374223
PMCPMC8497208
OpenAlexW3187280091

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.