ArticleJournal of veterinary internal medicine2021
Histopathologic, phenotypic, and molecular criteria to discriminate low-grade intestinal T-cell lymphoma in cats from lymphoplasmacytic enteritis.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Correlation between serum cobalamin concentration, histopathologic changes, and outcome in cats with chronic enteropathy.Journal of veterinary internal medicine · 2026Article
- Quantitative assessment of mucosal fibrosis and its correlation with disease severity and outcome in cats with chronic enteropathy.Journal of feline medicine and surgery · 2025Article
- Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats.Veterinary sciences · 2025Article
- Intestinal Ultrasonographic Measurements in Cats Diagnosed with Lymphoplasmacytic Enteritis and Low-Grade T-Cell Lymphoma Based on Either Histology/Immunohistochemistry or Clonality Testing-And Assessment of the Effects of Therapy on Wall Layering After 3 and 6 Months of Treatment.Animals : an open access journal from MDPI · 2025Article
- Review
- The Expression Levels of CD20 as a Prognostic Value in Feline B-Cell Nasal Lymphoma: A Pilot Study.Animals : an open access journal from MDPI · 2024Article
- Unbiased serum metabolomic analysis in cats with naturally occurring chronic enteropathies before and after medical intervention.Scientific reports · 2024Article
- Application of automated machine learning for histological evaluation of feline endoscopic samples.The Journal of veterinary medical science · 2024Article
- Treatment success in cats with chronic enteropathy is associated with a decrease in fecal calprotectin concentrations.Frontiers in veterinary science · 2024Article
- Flowcytometric data of intermediate-large cell gastrointestinal lymphoma presenting a gross mass in 32 cats - "let them glow in the flow".Frontiers in veterinary science · 2024Article
- Chronic Inflammatory Enteropathy and Low-Grade Intestinal T-Cell Lymphoma Are Associated with Altered Microbial Tryptophan Catabolism in Cats.Animals : an open access journal from MDPI · 2023Article
- Fecal Calprotectin Concentrations in Cats with Chronic Enteropathies.Veterinary sciences · 2023Article
- Utility of fluorescence imitating brightfield imaging microscopy for the diagnosis of feline chronic enteropathy.Veterinary pathology · 2023Observational
- Pathological Findings in Gastrointestinal Neoplasms and Polyps in 860 Cats and a Pilot Study on miRNA Analyses.Veterinary sciences · 2022Article
- Intestinal S100/Calgranulin Expression in Cats with Chronic Inflammatory Enteropathy and Intestinal Lymphoma.Animals : an open access journal from MDPI · 2022Article
- Dysbiosis index to evaluate the fecal microbiota in healthy cats and cats with chronic enteropathies.Journal of feline medicine and surgery · 2022Article
- Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas.Veterinary sciences · 2022Article
- Histopathologic, phenotypic, and molecular criteria to discriminate low-grade intestinal T-cell lymphoma in cats from lymphoplasmacytic enteritis.Journal of veterinary internal medicine · 2021Article
- Clinical, laboratory and ultrasonographic findings differentiating low-grade intestinal T-cell lymphoma from lymphoplasmacytic enteritis in cats.Journal of veterinary internal medicine · 2021Article
- The diagnostic relevance of mesenteric lymph node biopsy in small intestinal lymphoma in cats.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferentiation of low-grade intestinal T-cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists.
objectiveCharacterize histologic, immunohistochemical, and molecular features of LGITL and LPE. ANIMALS: Forty-four client-owned cats, 22 diagnosed with LGITL and 22 with LPE.
methodsProspective, cohort study. Clinical suspicion of LGITL or LPE was based on persistent gastrointestinal signs, unresponsive to empirical treatments. All cats underwent a standardized diagnostic evaluation, including biopsy (preferentially full-thickness), and were diagnosed with LGITL or LPE after review of clinical, laboratory, sonographic, histologic, immunohistochemical, and clonality results.
resultsA monomorphic lymphocytic population (22/22, 100%) and in-depth mucosal infiltration (15/22, 68%) were hallmarks of LGITL. Epithelial patterns (nests and plaques) were significantly more frequent in LGITL (11/22, 50%) than in LPE (1/22, 5%) cases (P = .001). A CD3+ lymphocytic apical-to-basal gradient was observed in 9/22 (41%) of LGITL vs 1/22 (5%) of LPE cases (P = .004). Most LPE cases (17/18, 94%) featured marked fibrosis in the superficial part of the lamina propria. The Ki-67 20%- and 30%-thresholds discriminated between LGITL and LPE within both the epithelium (specificity >95%) and lamina propria (specificity >95%), respectively. All LGITL cases were CD3+ pSTAT3- and pSTAT5+. T-cell receptor gamma chain gene rearrangements indicated monoclonality in 86% of LGITL cases. Surprisingly, 70% of LPE cases featured monoclonality (40%) or monoclonality on a polyclonal background (30%). CONCLUSIONS AND CLINICAL IMPORTANCE: We identified new histologic, immunohistochemical, and clonality criteria to distinguish LGITL from LPE.
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