ArticleEndocrine2021
Surgical outcomes in the pheochromocytoma surgery. Results from the PHEO-RISK STUDY.
Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Catecholamine-induced hypertensive crisis during laparoscopic adrenalectomy for pheochromocytoma.Updates in surgery · 2026Article
- Evaluation of differences in presentation and postoperative outcomes after adrenalectomy for pheochromocytoma according to age.Endocrine connections · 2026Article
- Symptomatic Pheochromocytoma: A Risk Model.Cancers · 2026Article
- Perioperative Management Challenges in Silent Pheochromocytoma: A Case Report and Literature Review.Clinical case reports · 2025Article
- Outcomes for Patients with Obesity Undergoing Adrenalectomy for Pheochromocytoma: An International Multicenter Analysis.Annals of surgical oncology · 2025Article
- Computed Tomography Radiomics Nomogram to Predict the Intraoperative Hypertensive Crisis of Abdominal Pheochromocytoma and Paraganglioma.Current medical imaging · 2025Article
- Diagnosis and management of adrenal incidentaloma: use of clinical judgment and evidence in dialog with the patient.Surgery today · 2024Review
- Hypotension with and Without Hypertensive Episodes During Endoscopic Adrenalectomy for Pheochromocytoma or Paraganglioma-Should Perioperative Treatment Be Individualized?Journal of clinical medicine · 2024Article
- Risk factors for postoperative complications after adrenalectomy for phaeochromocytoma: multicentre cohort study.BJS open · 2023Article
- Differences in intraoperative and surgical outcomes between normotensive pheochromocytomas and sympathetic paragangliomas (PPGLs) and hypertensive PPGLs: results from the PHEO-RISK STUDY.Journal of endocrinological investigation · 2023Article
- Risk factors for postoperative complications after pheochromocytoma and/or paraganglioma: a single-center retrospective study.Frontiers in oncology · 2023Article
- Tumour size in adrenal tumours: its importance in the indication of adrenalectomy and in surgical outcomes-a single-centre experience.Journal of endocrinological investigation · 2022Article
- Is the Adrenal Incidentaloma Functionally Active? An Approach-To-The-Patient-Based Review.Journal of clinical medicine · 2022Review
- Anesthetic management of a giant paraganglioma resection: a case report.BMC anesthesiology · 2022Article
- Article
- An alternative way to define hemodynamic instability in the pheochromocytoma surgery.Endocrine · 2022Article
- Predictive model of pheochromocytoma based on the imaging features of the adrenal tumours.Scientific reports · 2022Article
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20 authors.
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Abstract
purposeTo identify presurgical and surgical risk factors for postsurgical complications in the pheochromocytoma surgery.
methodsA retrospective study of pheochromocytomas submitted to surgery in ten Spanish hospitals between 2011 and 2021. Postoperative complications were classified according to Clavien-Dindo scale.
resultsOne hundred and sixty-two surgeries (159 patients) were included. Preoperative antihypertensive blockade was performed in 95.1% of the patients, being doxazosin in monotherapy (43.8%) the most frequent regimen. Patients pre-treated with doxazosin required intraoperative hypotensive treatment more frequently (49.4% vs 25.0%, P = 0.003) than patients treated with phenoxybenzamine, but no differences in the rate of intraoperative and postsurgical complications were observed. However, patients treated with phenoxybenzamine had a longer hospital stay (12.2 ± 11.16 vs 6.2 ± 6.82, P < 0.001) than those treated with doxazosin. Hypertension resolution was observed in 78.7% and biochemical cure in 96.6% of the patients. Thirty-one patients (19.1%) had postsurgical complications. Prolonged hypotension was the most common, in 9.9% (n = 16), followed by hypoglycaemia in six patients and acute renal failure in four patients. 13.0% of complications had a score ≥3 in the Clavien-Dindo scale. Postsurgical complications were more common in patients with diabetes, cerebrovascular disease, higher plasma glucose levels, higher urinary free metanephrine and norepinephrine, and with pheochromocytomas larger than 5 cm.
conclusionPreoperative medical treatment and postsurgical monitoring of pheochromocytoma should be especially careful in patients with diabetes, cerebrovascular disease, higher levels of plasma glucose and urine free metanephrine and norepinephrine, and with pheochromocytomas >5 cm, due to the higher risk of postsurgical complications.
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