Evidence map›Paper›PMID 34373986›Full record

ArticleJournal of molecular neuroscience : MN2022

HMGB1-RAGE Pathway Contributes to the Abnormal Migration of Endogenous Subventricular Zone Neural Progenitors in an Experimental Model of Focal Microgyria.

Yi-Wen Mei, Tian-Lan Huang, Xin Chen, Si-Xun Yu, Jie Li, Zhi Zhang, Yang He, Da-Qing Guo, Hai-Feng Shu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi-Wen MeiCollege of Medicine, Southwest Jiaotong University, Chengdu, China.
Tian-Lan HuangCollege of Medicine, Southwest Jiaotong University, Chengdu, China.
Xin ChenDepartment of Neurosurgery, General Hospital of Western Theater Command of PLA, Chengdu, China.
Si-Xun YuCollege of Medicine, Southwest Jiaotong University, Chengdu, China.
Jie LiCollege of Medicine, Southwest Jiaotong University, Chengdu, China.
Zhi ZhangDepartment of Neurosurgery, General Hospital of Western Theater Command of PLA, Chengdu, China.
Yang HeKey Laboratory of Advanced Technologies of Materials, Ministry of Education School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Da-Qing GuoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Hai-Feng ShuCollege of Medicine, Southwest Jiaotong University, Chengdu, China. shuhaifeng@swjtu.edu.cn.ORCID http://orcid.org/0000-0002-0193-1881
Southwest Jiaotong University · CNChinese General Hospital College of Nursing and Liberal Arts · PHUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal migration of subventricular zone (SVZ)-derived neural progenitor cells (SDNPs) is involved in the pathological and epileptic processes of focal cortical dysplasias (FCDs), but the underlying mechanisms are not clear. Recent studies indicated that high mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) are widely expressed in epileptic specimens of FCDs, which suggests that the HMGB1-RAGE pathway is involved in the pathological and/or epileptic processes of FCDs. The present study used Nestin-GFP

Indexed as

HMGB1 ProteinNeural Stem CellsAnimalsLateral VentriclesMiceModels, TheoreticalReceptor for Advanced Glycation End ProductsHMGB1 ProteinReceptor for Advanced Glycation End ProductsEpileptiform dischargeFreeze lesionHigh mobility group box 1MigrationNeural progenitorsReceptor for advanced glycation end products

Identifiers

PMID34373986
OpenAlexW3188691589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.