SynthesisIntensive care medicine2021
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 72 citations in OpenAlex.
- Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition.BMC medicine · 2026Trial
- Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study.Intensive care medicine · 2023Trial
- Immune responses and immunomodulation in sepsis: a call for identifying treatable mechanisms.Intensive care medicine · 2026Article
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- The impact of community-acquired critical sepsis on long-term mortality and morbidity-a nationwide cohort study.Scientific reports · 2026Article
- Article
- Pediatric Critical Illness, Immunometabolism and Cardiovascular Risk: A Narrative Review.Minerva pediatrics · 2026Article
- The risk of cardiovascular events following community-acquired sepsis: a nationwide cohort study in Sweden.Epidemiology and infection · 2026Article
- Mortality Trends in the United States due to Concurrent Heart Failure, Atrial Fibrillation/Flutter, and Sepsis.medRxiv : the preprint server for health sciences · 2026Article
- Sepsis insult generates different vascular response phenotypes: an unsupervised time-series clustering preclinical study.Scientific reports · 2026Article
- Prior Use of GLP-1 Receptor Agonists versus SGLT2 Inhibitors and Clinical Outcomes After Sepsis in Patients with Type 2 Diabetes: A Propensity Score-Matched Cohort Study.Drug design, development and therapy · 2026Article
- Mortality Trends in the United States due to Concurrent Heart Failure, Atrial Fibrillation/Flutter and Sepsis.Cardiology and cardiovascular medicine · 2026Article
- Construction of a Risk Prediction Model for Stroke Occurrence in Septic Shock Patients: A Combined Analysis Using LASSO and Multivariate Logistic Regression.International journal of general medicine · 2026Article
- Survival outcomes, determinants, and hemodynamic trajectories with intravenous βFrontiers in pharmacology · 2026Article
- Stress management by benzodiazepines in septic shock and critical illness: mechanistic and clinical evidence supporting alternative sedative strategies.Cell stress · 2026Article
- Toll-like receptors in infectious myocarditis: pathogen-specific recognition, spatiotemporal dynamic regulation and clinical translation.Frontiers in cardiovascular medicine · 2026Review
- Long-term cardiovascular complications in COVID-19 survivors according to disease severity.Scientific reports · 2025Article
- Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study.European heart journal · 2025Observational
- Disease trajectory and mortality among sepsis patients: a prospective cohort study.BMC infectious diseases · 2025Article
- Age-related differences in sepsis outcomes: A comparative analysis of elderly and very elderly ICU patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 10 institutions in 4 countries.
Funding
Abstract
purposeWe aimed to determine the association between sepsis and long-term cardiovascular events.
methodsWe conducted a systematic review of observational studies evaluating post-sepsis cardiovascular outcomes in adult sepsis survivors. MEDLINE, Embase, and the Cochrane Controlled Trials Register and Database of Systematic Reviews were searched from inception until April 21st, 2021. Two reviewers independently extracted individual study data and evaluated risk of bias. Random-effects models estimated the pooled crude cumulative incidence and adjusted hazard ratios (aHRs) of cardiovascular events compared to either non-septic hospital survivors or population controls. Primary outcomes included myocardial infarction, stroke, and congestive heart failure; outcomes were analysed at maximum reported follow-up (from 30 days to beyond 5 years post-discharge).
resultsOf 12,649 screened citations, 27 studies (25 cohort studies, 2 case-crossover studies) were included with a median of 4,289 (IQR 502-68,125) sepsis survivors and 18,399 (IQR 4,028-83,506) controls per study. The pooled cumulative incidence of myocardial infarction, stroke, and heart failure in sepsis survivors ranged from 3 to 9% at longest reported follow-up. Sepsis was associated with a higher long-term risk of myocardial infarction (aHR 1.77 [95% CI 1.26 to 2.48]; low certainty), stroke (aHR 1.67 [95% CI 1.37 to 2.05]; low certainty), and congestive heart failure (aHR 1.65 [95% CI 1.46 to 1.86]; very low certainty) compared to non-sepsis controls.
conclusionsSurviving sepsis may be associated with a long-term, excess hazard of late cardiovascular events which may persist for at least 5 years following hospital discharge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.