Evidence map›Paper›PMID 34373758›Full record

ArticleTheranostics2021

Pulmonary circulation-mediated heart targeting for the prevention of heart failure by inhalation of intrinsically bioactive nanoparticles.

Chao Liu, Liyuan Chen, Yongchang Ma, Kaiyao Hu, Peng Wu, Lina Pan, Haiyan Chen, Lanlan Li, Houyuan Hu, Jianxiang Zhang

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2026
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  5. Navigating theNanoscale advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chao LiuDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Liyuan ChenDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Yongchang MaDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Kaiyao HuDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Peng WuDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Lina PanDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Haiyan ChenDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Lanlan LiDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Houyuan HuDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Jianxiang ZhangDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Army Medical University · CNSouthwest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure is a serious clinical and public health problem. Currently there is an unmet demand for effective therapies for heart failure. Herein we reported noninvasive inhalation delivery of nanotherapies to prevent heart failure.

Indexed as

A549 CellsAdministration, InhalationAnimalsAnti-Inflammatory Agentsbeta-CyclodextrinsCardiomyopathiesCell LineDoxorubicinDrug Delivery SystemsHeartHeart FailureHumansInflammationLungMiceNanoparticlesAnti-Inflammatory Agentsbeta-CyclodextrinsDoxorubicinReactive Oxygen Speciesbioactive nanoparticlescardiac dysfunctionheart failureinhalation deliverynanotherapytargeted therapy

Identifiers

PMID34373758
PMCPMC8343995
OpenAlexW3186379596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.