Evidence map›Paper›PMID 34373702›Full record

ArticleExperimental and therapeutic medicine2021

Morphine pretreatment protects against cerebral ischemic injury via a cPKCγ-mediated anti-apoptosis pathway.

Xiao-Yan Zhao, Jun-Fa Li, Tian-Zuo Li, Chu-Xiong Pan, Fu-Shan Xue, Gu-Yan Wang

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao-Yan ZhaoDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Jun-Fa LiDepartment of Neurobiology, Capital Medical University; Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, P.R. China.
Tian-Zuo LiDepartment of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.
Chu-Xiong PanDepartment of Anesthesiology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, P.R. China.
Fu-Shan XueDepartment of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Gu-Yan WangDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Capital Medical University · CNBeijing Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been reported that morphine pretreatment (MP) can exert neuroprotective effects, and that protein kinase C (PKC) participates in the initiation and development of ischemic/hypoxic preconditioning in the brain. However, it remains unknown whether PKC is involved in MP-induced neuroprotection. The aim of the present study, which included

Indexed as

micemiddle cerebral artery occlusionmorphineneuroprotectionprotein kinase C

Identifiers

PMID34373702
PMCPMC8343874
OpenAlexW3181412016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.