Evidence map›Paper›PMID 34373698›Full record

ArticleComputational and mathematical methods in medicine2021

Naloxone Protects against Lipopolysaccharide-Induced Neuroinflammation and Microglial Activation via Inhibiting ATP-Sensitive Potassium Channel.

Zhijia Tang, Xiaobao Shao, Jun Wu, Hucheng Chen, Anyu Zhang, Fei Xu, He Ping, Shiwei Li, Chunyan Liu, Yijun Li and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Zhijia TangDepartment of Medicine, Tongling Technology College, Anhui 244061, China.ORCID https://orcid.org/0000-0002-8390-312X
Xiaobao ShaoDepartment of Transfusion Medicine, The Affiliated Nanjing Traditional Chinese Medicine Hospital, Nanjing University of Chinese Medicine, Nanjing 210022, China.ORCID https://orcid.org/0000-0001-9281-2476
Jun WuDepartment of Clinical Laboratory, Nanjing Brain Hospital & The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID https://orcid.org/0000-0002-5463-8128
Hucheng ChenDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Anyu ZhangDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Fei XuDepartment of Transfusion Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
He PingDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Shiwei LiDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Chunyan LiuDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Yijun LiDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Xue XueDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.ORCID https://orcid.org/0000-0003-4849-9069
Binbin YuanDepartment of Neurosurgery, Haimen People's Hospital, Nantong 226100, China.ORCID https://orcid.org/0000-0003-3770-3861
Nanjing Medical University · CNNanjing Brain Hospital · CNNanjing University of Chinese Medicine · CNTongling University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study was to evaluate the anti-inflammatory effects and underlying mechanism of naloxone on lipopolysaccharide- (LPS-) induced neuronal inflammation and microglial activation.

methodsLPS-treated microglial BV-2 cells and mice were used to investigate the anti-inflammatory effects of naloxone.

resultsThe results showed that naloxone dose-dependently promoted cell proliferation in LPS-induced BV-2 cells, downregulated the expression of proinflammatory cytokines (TNF-

conclusionNaloxone prevented LPS-induced neuroinflammation and microglial activation partially through the KATP channel. These findings might highlight the potential of naloxone in neuroinflammation therapy.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalBehavior, AnimalCell LineCell ProliferationComputational BiologyDisease Models, AnimalInflammationKATP ChannelsLipopolysaccharidesMiceMice, Inbred BALB CMicrogliaNaloxoneNarcotic AntagonistsNeurodegenerative DiseasesAnti-Inflammatory Agents, Non-SteroidalKATP ChannelsLipopolysaccharidesNaloxoneNarcotic Antagonists

Identifiers

PMID34373698
PMCPMC8349287
OpenAlexW3187507429

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.