ReviewMissouri medicine
Hydrogel-Based Spheroid Models of Glioblastoma for Drug Screening Applications.
Review in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Standardized Workflow for the Generation of Patient-Derived Glioblastoma Spheroids.Methods and protocols · 2026Article
- Recent Developments in Glioblastoma-On-A-Chip for Advanced Drug Screening Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Review
- Biomaterial-basedCancer pathogenesis and therapy · 2023Review
- Infantile hemangioma models: is the needle in a haystack?Journal of translational medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma multiforme (GBM) is the most aggressive brain tumor, with median patient survival of 12-15 months even after treatment. To facilitate basic research as well as treatment development, bioengineered GBM models that adequately recapitulate aspects of the in vivo tumor microenvironment are greatly needed. Multicellular spheroids are a well-accepted model in tumor biology as well as drug screening because they recapitulate many of the solid tumor characteristics, such as hypoxic core and cell-cell communication. There are multiple approaches for growing GBM cells into tumor spheroids - non-adherent plastic dishes, hanging drop, bioreactors, and hydrogels, amongst others. Suspension spheroid models offer ease of growth, uniformity, and overall lower cost, but neglect the cell-matrix interactions, while hydrogel-based spheroids capture cell-matrix interactions and allow co-cultures with stromal cells. In this review, we summarize various approaches to fabricate GBM spheroid models as well as GBM spheroid characteristics and chemotherapeutic responsiveness as a function of hydrogel matrix encapsulation and properties, in order to advance therapies.
Indexed as
Identifiers
34373670PMC8343644What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.