Evidence map›Paper›PMID 34373667›Full record

ArticleMissouri medicine

Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain.

Timothy M Doyle, Kathryn Braden, Caron M Harada, Fatma Mufti, Rachel M Schafer, Daniela Salvemini

Open access · greenAbstract read
In one paragraph

Article in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Timothy M DoyleDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Kathryn BradenDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Caron M HaradaDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Fatma MuftiDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Rachel M SchaferDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Daniela SalveminiDepartment of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri.
Saint Louis University · US

Funding

Pharmacological Sciences Training GrantT32GM008306 · NIGMS · SAINT LOUIS UNIVERSITY · PI EGAN, TERRANCE M, WALKER, JOHN K. · 1990 to 2020
$3.6M
Role of opioid-induced S1P/S1PR1 axis activation in neuroinflammatory reponsesR01DA043543 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA, VANDERAH, TODD W · 2018 to 2020
$1.7M
Role of peroxynitrite in morphine hyperalgesia and toleranceR01DA024074 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2008 to 2012
$1.7M
A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathyR01CA169519 · NCI · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2013 to 2017
$1.5M
Targeting the relief of chronic pain with orally active peroxynitrite decompositiRC1AR058231 · NIAMS · SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE · PI NEUMANN, WILLIAM, SALVEMINI, DANIELA · 2009 to 2010
$974k
Role of ceramide in morphine hyperalgesia and toleranceR21DA023056 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2008 to 2009
$392k
Preserving opioid analgesia using a novel adenosinergic approachR21DA040305 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2015 to 2016
$377k
NCI NIH HHS R01 CA169519NIAMS NIH HHS RC1 AR058231NIDA NIH HHS R01 DA024074NIDA NIH HHS R01 DA043543NIDA NIH HHS R21 DA023056NIDA NIH HHS R21 DA040305NIGMS NIH HHS T32 GM008306
6 · The paper itself

Abstract

Chronic neuropathic pain is currently a major health issue in U.S. complicated by the lack of non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling pathways involved in the transition of acute to chronic neuropathic pain and the identification of several targets for therapeutic intervention. Our translational approach has facilitated the advancement of novel medicines for chronic neuropathic pain that are in advanced clinical development and clinical trials.

Indexed as

Chronic PainNeuralgiaAnalgesics, OpioidHumansAnalgesics, Opioid

Identifiers

PMID34373667
PMCPMC8343628
OpenAlexW3188134142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.