Evidence map›Paper›PMID 34373643›Full record

Observational studyNature biotechnology2022

Remote smartphone monitoring of Parkinson's disease and individual response to therapy.

Larsson Omberg, Elias Chaibub Neto, Thanneer M Perumal, Abhishek Pratap, Aryton Tediarjo, Jamie Adams, Bastiaan R Bloem, Brian M Bot, Molly Elson, Samuel M Goldman and 12 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Nature biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 3 countries.

Larsson Omberg *Sage Bionetworks, Seattle, WA, USA. larsson.omberg@sagebionetworks.org.ORCID http://orcid.org/0000-0002-4719-9120
Elias Chaibub Neto *Sage Bionetworks, Seattle, WA, USA. elias.chaibub.neto@sagebionetworks.org.ORCID http://orcid.org/0000-0002-9575-861X
Thanneer M PerumalSage Bionetworks, Seattle, WA, USA.
Abhishek PratapSage Bionetworks, Seattle, WA, USA.
Aryton TediarjoSage Bionetworks, Seattle, WA, USA.
Jamie AdamsCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.
Bastiaan R BloemRadboud University Medical Center; Donders Institute for Brain, Cognition and Behaviour; Department of Neurology, Nijmegen, the Netherlands.
Brian M BotSage Bionetworks, Seattle, WA, USA.
Molly ElsonCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-3313-1173
Samuel M GoldmanDepartment of Neurology, University of California-San Francisco and Parkinson's Disease Research, Education and Clinical Center, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Michael R KellenSage Bionetworks, Seattle, WA, USA.
Karl KieburtzCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.
Arno KleinSage Bionetworks, Seattle, WA, USA.
Max A LittleSchool of Computer Science, University of Birmingham, Birmingham, UK.
Ruth SchneiderCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.
Christine SuverSage Bionetworks, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2986-385X
Christopher TarolliCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.
Caroline M TannerDepartment of Neurology, University of California-San Francisco and Parkinson's Disease Research, Education and Clinical Center, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Andrew D TristerBill & Melinda Gates Foundation, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7070-0139
John WilbanksSage Bionetworks, Seattle, WA, USA.
E Ray DorseyCenter for Health and Technology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-5140-1248
Lara M MangraviteSage Bionetworks, Seattle, WA, USA. ara.mangravite@sagebionetworks.org.
Sage Bionetworks · USUniversity of Rochester Medical Center · USSan Francisco VA Medical Center · USGates Foundation · USMassachusetts Institute of Technology · USRadboud University Nijmegen · NL

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

Remote health assessments that gather real-world data (RWD) outside clinic settings require a clear understanding of appropriate methods for data collection, quality assessment, analysis and interpretation. Here we examine the performance and limitations of smartphones in collecting RWD in the remote mPower observational study of Parkinson's disease (PD). Within the first 6 months of study commencement, 960 participants had enrolled and performed at least five self-administered active PD symptom assessments (speeded tapping, gait/balance, phonation or memory). Task performance, especially speeded tapping, was predictive of self-reported PD status (area under the receiver operating characteristic curve (AUC) = 0.8) and correlated with in-clinic evaluation of disease severity (r = 0.71; P < 1.8 × 10

Indexed as

Parkinson DiseaseSmartphoneGaitHumansMovementSeverity of Illness Index

Identifiers

PMID34373643
PMCPMC12812035
OpenAlexW3189407326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.