Evidence map›Paper›PMID 34373623›Full record

ReviewNature reviews. Immunology2021

Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape.

John S Tregoning, Katie E Flight, Sophie L Higham, Ziyin Wang, Benjamin F Pierce

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 665 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
665citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

665 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  20. Inflammatory mediators of mRNA vaccine-induced adverse reactions in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
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605 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John S TregoningDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK. john.tregoning@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8093-8741
Katie E FlightDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
Sophie L HighamDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.
Ziyin WangDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1110-808X
Benjamin F PierceDepartment of Infectious Disease, St Mary's Campus, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0834-5201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we provide a snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern. Where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease. Nonetheless, there are still significant challenges in ensuring equitable vaccine access around the globe and lessons that can be learned for controlling this pandemic and for the next pandemic.

Indexed as

Clinical Trials as TopicCOVID-19 VaccinesHealth Services AccessibilityHumansSARS-CoV-2World Health OrganizationCOVID-19 Vaccines

Identifiers

PMID34373623
PMCPMC8351583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.