ArticleCommunications biology2021
Predicting the taxonomic and environmental sources of integron gene cassettes using structural and sequence homology of attC sites.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mobile Genetic Elements as Key Drivers of Bacterial Evolution and Adaptation in Agroecosystems.Microbial ecology · 2026Review
- Review
- Trade-off between canonical and unusual recombination sites promotes diversity and stability of gene cassette arrays of mobile integrons.Scientific reports · 2026Article
- Diverse enteric bacterial, viral, and parasitic pathogen genes are shed in animal feces in Indiana.PloS one · 2026Article
- Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons.Nucleic acids research · 2025Article
- Adaptative and ancient co-evolution of integrons withMicrobial genomics · 2025Article
- Natural Microbiota of Dogs and Cats as a Source and Vector of Resistance Genes-Clinical Significance.International journal of molecular sciences · 2025Review
- Emergence and characterization of a ST852Frontiers in cellular and infection microbiology · 2025Article
- Riverine antibiotic resistome along an anthropogenic gradient.Frontiers in microbiology · 2025Article
- Global genomic epidemiology ofMicrobial genomics · 2024Article
- Microbial biofilms on macroalgae harbour diverse integron gene cassettes.Microbiology (Reading, England) · 2024Article
- Horizontal gene transfer in plant microbiomes: integrons as hotspots for cross-species gene exchange.Frontiers in microbiology · 2024Article
- Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment.Scientific reports · 2023Article
- Integrons in the development of antimicrobial resistance: critical review and perspectives.Frontiers in microbiology · 2023Review
- Identification of integrons and gene cassette-associated recombination sites in bacteriophage genomes.Frontiers in microbiology · 2023Article
- Discovery of integrons in Archaea: Platforms for cross-domain gene transfer.Science advances · 2022Article
- Antibiotic Resistance Genes in River Biofilms: A Metagenomic Approach toward the Identification of Sources and Candidate Hosts.Environmental science & technology · 2022Article
- IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella.Microorganisms · 2022Article
- Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities.Microbial genomics · 2022Article
- Whole genome sequencing of OXA-232-producingFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrons are bacterial genetic elements that can capture mobile gene cassettes. They are mostly known for their role in the spread of antibiotic resistance cassettes, contributing significantly to the global resistance crisis. These resistance cassettes likely originated from sedentary chromosomal integrons, having subsequently been acquired and disseminated by mobilised integrons. However, their taxonomic and environmental origins are unknown. Here, we use cassette recombination sites (attCs) to predict the origins of those resistance cassettes now spread by mobile integrons. We modelled the structure and sequence homology of 1,978 chromosomal attCs from 11 different taxa. Using these models, we show that at least 27% of resistance cassettes have attCs that are structurally conserved among one of three taxa (Xanthomonadales, Spirochaetes and Vibrionales). Indeed, we found some resistance cassettes still residing in sedentary chromosomal integrons of the predicted taxa. Further, we show that attCs cluster according to host environment rather than host phylogeny, allowing us to assign their likely environmental sources. For example, the majority of β-lactamases and aminoglycoside acetyltransferases, the two most prevalent resistance cassettes, appear to have originated from marine environments. Together, our data represent the first evidence of the taxonomic and environmental origins of resistance cassettes spread by mobile integrons.
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