Evidence map›Paper›PMID 34373571›Full record

ArticleScientific reports2021

Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [

Nathalie Mertens, Mark E Schmidt, Anja Hijzen, Donatienne Van Weehaeghe, Paulien Ravenstijn, Marleen Depre, Jan de Hoon, Koen Van Laere, Michel Koole

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.European journal of nuclear medicine and molecular imaging · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. The Coming of Age of the P2X7 Receptor in Diagnostic Medicine.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathalie MertensNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital and KU Leuven, Herestraat 49, 3000, Leuven, Belgium. nathalie.mertens@kuleuven.be.
Mark E SchmidtJanssen Research and Development, Beerse, Belgium.
Anja HijzenJanssen Research and Development, Beerse, Belgium.
Donatienne Van WeehaegheNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital and KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Paulien RavenstijnJanssen Research and Development, Beerse, Belgium.
Marleen DepreCenter for Clinical Pharmacology, University Hospital and KU Leuven, Leuven, Belgium.
Jan de HoonCenter for Clinical Pharmacology, University Hospital and KU Leuven, Leuven, Belgium.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital and KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Michel KooleNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital and KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[

Indexed as

AdultBrainFluorine RadioisotopesHumansImaging, Three-DimensionalLigandsMagnetic Resonance AngiographyMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsReceptors, Purinergic P2X7Young AdultFluorine-18Fluorine RadioisotopesLigandsP2RX7 protein, humanRadiopharmaceuticalsReceptors, Purinergic P2X7

Identifiers

PMID34373571
PMCPMC8352986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.