Evidence map›Paper›PMID 34373514›Full record

ArticleScientific reports2021

Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model.

Ik Jun Moon, Mi Ra Yun, Hae Kyeong Yoon, Keon Hee Lee, Sun Young Choi, Woo Jin Lee, Sung Eun Chang, Chong Hyun Won

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. European S2k Guideline on Chronic PruritusActa dermato-venereologica · 2025
    Guideline
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Polynucleotides Enhance Skin Barrier Function and Reduce Inflammation in a 2,4-Dinitrochlorobenzene-Induced Mouse Model of Atopic Dermatitis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Ik Jun MoonDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Mi Ra YunDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hae Kyeong YoonAsan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Keon Hee LeeDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Sun Young ChoiDepartment of Dermatology, Ilsan Paik Hospital, Inje University College of Medicine, Gyeonggi-do, Republic of Korea.
Woo Jin LeeDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Sung Eun ChangDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Chong Hyun WonDepartment of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. drwon@amc.seoul.kr.
Ulsan College · KRAsan Medical Center · KRUniversity of Ulsan · KRInje University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) has been incorporated into various fields, including promotion of cutaneous wound healing. Atopic dermatitis (AD) is a chronic cutaneous condition characterized by inflammation-induced skin wounds and impaired skin barrier function. To investigate whether CAP may improve AD using an animal model. Dermatophagoides farinae extracts (DFE)-induced murine models of AD were used in this study. The plasma-treated group received a total of 6 CAP treatments during 2 weeks, while the control group did not receive any treatment. Differences in dermatitis severity, transepidermal water loss (TEWL), serum level of immunoglobulin (Ig) E and epidermal thickness were evaluated in both groups. The dermatitis severity was significantly improved by CAP treatment. TEWL was lower in the plasma-treated group compared with the non-treated control group. Serum Ig E dropped significantly after treatment with CAP. Difference in epidermal thickness of the ear skin was not significant between the plasma-treated and non-treated groups. Localized treatment of AD with CAP decreases dermatitis severity, TEWL, and serum Ig E level. These results show CAP's potentials as a novel therapeutic modality for AD.

Indexed as

AnimalsDermatitis, AtopicDermatophagoides farinaeDisease Models, AnimalEpidermisImmunoglobulin EInflammationMaleMiceSkinImmunoglobulin E

Identifiers

PMID34373514
PMCPMC8352957
OpenAlexW3191571991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.