Evidence map›Paper›PMID 34373481›Full record

ArticleScientific reports2021

State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.

Joseph Santos-Sacchi, Dhasakumar Navaratnam, Winston J T Tan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  4. A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph Santos-SacchiSurgery (Otolaryngology), Yale University School of Medicine, BML 224, 333 Cedar Street, New Haven, CT, 06510, USA. joseph.santos-sacchi@yale.edu.
Dhasakumar NavaratnamSurgery (Otolaryngology), Yale University School of Medicine, BML 224, 333 Cedar Street, New Haven, CT, 06510, USA.
Winston J T TanSurgery (Otolaryngology), Yale University School of Medicine, BML 224, 333 Cedar Street, New Haven, CT, 06510, USA.
Yale University · US

Funding

Membrane properties of the OHC systemR01DC016318 · NIDCD · YALE UNIVERSITY · PI DHASAKUMAR S NAVARATNAM, JOSEPH R SANTOS-SACCHI · 2017 to 2026
$6.7M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC016318
6 · The paper itself

Abstract

The outer hair cell (OHC) membrane harbors a voltage-dependent protein, prestin (SLC26a5), in high density, whose charge movement is evidenced as a nonlinear capacitance (NLC). NLC is bell-shaped, with its peak occurring at a voltage, V

Indexed as

Acoustic StimulationAnimalsCochleaElectric CapacitanceGuinea PigsHair Cells, Auditory, OuterKineticsMechanotransduction, CellularMembrane PotentialsModels, BiologicalNonlinear DynamicsPatch-Clamp TechniquesProtein ConformationProteinsPres protein, Cavia porcellusProteins

Identifiers

PMID34373481
PMCPMC8352928
OpenAlexW3188999456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.