Evidence map›Paper›PMID 34373445›Full record

ArticleCell discovery2021

The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance.

Chuying Huang, Hongqin Ying, Xibiao Yang, Yuan Gao, Tuo Li, Bo Wu, Meng Ren, Zixiong Zhang, Jun Ding, Jianhua Gao and 8 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Chuying Huang *Hubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China. huangchuying2008@126.com.
Hongqin Ying *Hubei Selenium Industrial Technology Research Institute, Enshi Autonomous Prefecture Academy of Agriculture Sciences, Enshi, Hubei, China.
Xibiao Yang *Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yuan GaoDepartment of Chemistry and Molecular Biology, University of Gothenburg, SE 405 30, Gothenburg, Sweden.
Tuo LiHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Bo WuHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Meng RenCenter for Bioinformatics and Computational Biology, and the Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.
Zixiong ZhangHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Jun DingHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Jianhua GaoSouth China Potato Research Center, Enshi Autonomous Prefecture Academy of Agricultural Sciences, Enshi, Hubei, China.
Dan WenBureau of Agricultural & Rural Affairs of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Xingzhi YeSouth China Potato Research Center, Enshi Autonomous Prefecture Academy of Agricultural Sciences, Enshi, Hubei, China.
Ling LiuWuhan Frasergen Bioinformatics Co., Ltd., Wuhan, Hubei, China.
Huan WangWuhan Frasergen Bioinformatics Co., Ltd., Wuhan, Hubei, China.
Guogen SunHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Yi ZouHubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Nansheng ChenInstitute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong, China.ORCID http://orcid.org/0000-0002-0615-7215
Li Wang *Hubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture · CNEnshi Tujia and Miao Autonomous Prefecture Academy of Agricultural Sciences · CNEast China Normal University · CNHubei University for Nationalities · CNSichuan University · CNSimon Fraser University · CAUniversity of Gothenburg · SE

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81660503
6 · The paper itself

Abstract

Cardamine enshiensis is a well-known selenium (Se)-hyperaccumulating plant. Se is an essential trace element associated with many health benefits. Despite its critical importance, genomic information of this species is limited. Here, we report a chromosome-level genome assembly of C. enshiensis, which consists of 443.4 Mb in 16 chromosomes with a scaffold N50 of 24 Mb. To elucidate the mechanism of Se tolerance and hyperaccumulation in C. enshiensis, we generated and analyzed a dataset encompassing genomes, transcriptomes, and metabolomes. The results reveal that flavonoid, glutathione, and lignin biosynthetic pathways may play important roles in protecting C. enshiensis from stress induced by Se. Hi-C analysis of chromatin interaction patterns showed that the chromatin of C. enshiensis is partitioned into A and B compartments, and strong interactions between the two telomeres of each chromosome were correlated with histone modifications, epigenetic markers, DNA methylation, and RNA abundance. Se supplementation could affect the 3D chromatin architecture of C. enshiensis at the compartment level. Genes with compartment changes after Se treatment were involved in selenocompound metabolism, and genes in regions with topologically associated domain insulation participated in cellular responses to Se, Se binding, and flavonoid biosynthesis. This multiomics research provides molecular insight into the mechanism underlying Se tolerance and hyperaccumulation in C. enshiensis.

Identifiers

PMID34373445
PMCPMC8352907
OpenAlexW3187169067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.