Evidence map›Paper›PMID 34373155›Full record

ReviewTrends in endocrinology and metabolism: TEM2021

SARS-CoV-2 and pancreas: a potential pathological interaction?

Shirin Geravandi, Azam Mahmoudi-Aznaveh, Zahra Azizi, Kathrin Maedler, Amin Ardestani

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  5. COVID-19 and type 2 diabetes mellitus: implications in pancreatic beta cells.Revista medica del Instituto Mexicano del Seguro Social · 2024
    Review
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  9. A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022
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  16. Diabetes and SARS-CoV-2-Is There a Mutual Connection?Frontiers in cell and developmental biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shirin GeravandiCentre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Azam Mahmoudi-AznavehDepartment of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahra AziziDepartment of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Kathrin MaedlerCentre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany. Electronic address: kmaedler@uni-bremen.de.
Amin ArdestaniCentre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: ardestani.amin@gmail.com.
University of Bremen · DETehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19-diabetes fatal bidirectional relationship.

Indexed as

Acinar CellsAngiotensin-Converting Enzyme 2COVID-19Diabetes MellitusGlucagon-Secreting CellsHumansInsulin-Secreting CellsIslets of LangerhansPancreasReceptors, CoronavirusSARS-CoV-2Serine EndopeptidasesViral TropismAngiotensin-Converting Enzyme 2Receptors, CoronavirusSerine EndopeptidasesTMPRSS2 protein, humanACE2COVID-19diabetesinflammationinsulinisletspancreasSARS-CoV-2β-cell

Identifiers

PMID34373155
PMCPMC8302839
OpenAlexW3185661302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.