Evidence map›Paper›PMID 34373135›Full record

ArticleUltrasound in medicine & biology2021

Strain Estimation of the Murine Right Ventricle Using High-Frequency Speckle-Tracking Ultrasound.

Conner C Earl, Frederick W Damen, Melissa Yin, Kristiina L Aasa, Sarah K Burris, Craig J Goergen

Open access · greenAbstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Mouse Cardiovascular Imaging.Current protocols · 2024
    Review
  2. Article
  3. Article
  4. Standardisation and future of preclinical echocardiography.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Conner C EarlWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Frederick W DamenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Melissa YinFujifilm VisualSonics Inc., Toronto, Ontario, Canada.
Kristiina L AasaFujifilm VisualSonics Inc., Toronto, Ontario, Canada.
Sarah K BurrisFujifilm VisualSonics Inc., Toronto, Ontario, Canada.
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA. Electronic address: cgoergen@purdue.edu.
FujiFilm VisualSonics (Canada) · CAPurdue University West Lafayette · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
NRSA Training CoreTL1TR002531 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI FOTI, DANIEL JUSTIN, HURLEY, THOMAS D. · 2018 to 2022
$2.5M
NCATS NIH HHS TL1 TR002531NCATS NIH HHS UL1 TR002529NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

Right ventricular (RV) strain measurements from ultrasound via speckle-tracking techniques are being used more frequently as a non-invasive diagnostic tool for a variety of cardiopulmonary pathologies. However, despite the clinical utility of ultrasound RV strain measurements, quantification of RV strain in rodents remains difficult owing to unique image artifacts and non-standardized methodologies. We demonstrate here a simple approach for measuring RV strain in both mice and rats using high-frequency ultrasound and automated speckle tracking. Our results show estimated peak RV free-wall longitudinal strain values (mean ± standard error of the mean) in mice (n = 15) and rats (n = 5) of, respectively, -10.38% ± 0.4% and -4.85% ± 0.42%. We further estimated the 2-D Green-Lagrange strain within the RV free wall, with longitudinal components estimated at -5.7% ± 0.48% in mice and -2.1% ± 0.28% in rats. These methods and data may provide a foundation for future work aimed at evaluating murine RV strain levels in different disease models.

Indexed as

Heart VentriclesVentricular Dysfunction, RightAnimalsEchocardiographyHeartMiceRatsUltrasonographyCardiacEchocardiographyMouseMurineRatRight ventricleStrainUltrasound

Identifiers

PMID34373135
PMCPMC8488001
OpenAlexW3191321518

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.