Evidence map›Paper›PMID 34373125›Full record

ArticleTrends in neurosciences2021

The Na

Leonard K Kaczmarek

Open access · greenAbstract readComment
In one paragraph

Article in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Leonard K KaczmarekDepartment of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: leonard.kaczmarek@yale.edu.
Yale University · US

Funding

EXPRESSION OF ION CHANNELS IN THE AUDITORY SYSTEMR01DC001919 · NIDCD · YALE UNIVERSITY · PI KACZMAREK, LEONARD K · 1993 to 2025
$9.7M
Cellular Regulation of Sodium-activated Potassium ChannelsR01NS102239 · NINDS · YALE UNIVERSITY · PI LEONARD K KACZMAREK · 2018 to 2026
$3.5M
Role of viral infections in potassium channel-related cerebellar ataxiaR01NS111242 · NINDS · YALE UNIVERSITY · PI IWASAKI, AKIKO, KACZMAREK, LEONARD K · 2019 to 2023
$2.7M
NIDCD NIH HHS R01 DC001919NINDS NIH HHS R01 NS102239NINDS NIH HHS R01 NS111242
6 · The paper itself

Abstract

Mutations that increase sodium currents in excitatory neurons typically produce hyperexcitability and epileptic seizures. Paradoxically, mutations that reduce Na

Indexed as

EpilepsySodiumAction PotentialsHumansNeuronsSeizuresSodiumepilepsyNa(V)1.2potassium channelspyramidal neurons

Identifiers

PMID34373125
PMCPMC8813127
OpenAlexW3187662175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.