Evidence map›Paper›PMID 34373037›Full record

ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2021

Association between modified frailty index and surgical outcomes in intradural skull base surgery.

Khodayar Goshtasbi, Arash Abiri, Brandon M Lehrich, Mehdi Abouzari, Harrison W Lin, Hamid R Djalilian, Frank P K Hsu, Edward C Kuan

Abstract read
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In one paragraph

Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
Arash AbiriDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
Brandon M LehrichMedical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA.
Mehdi AbouzariDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
Harrison W LinDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
Frank P K HsuDepartment of Neurological Surgery, University of California, Irvine, Orange, CA, USA.
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA; Department of Neurological Surgery, University of California, Irvine, Orange, CA, USA. Electronic address: eckuan@uci.edu.

Funding

NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
NCATS NIH HHS TL1 TR001415
6 · The paper itself

Abstract

The objective of this study is to evaluate the impact of preoperative frailty on short-term outcomes following intradural resection of skull base lesions. The 2005-2017 ACS-NSQIP database was queried for 30-day post-operative outcomes of patients undergoing intradural resection of the skull base, extracted by CPT codes 61601, 61606, 61608, and 61616. Five-item modified frailty index (mFI) was calculated based on the history of diabetes mellitus, chronic obstructive pulmonary disease, congestive heart failure, chronic hypertension, and functional status. A total of 701 patients (58.8% female, 72.0% white) were included with a mean age of 51.8 ± 14.7 years. Compared to patients with mFI = 0 (n = 403), patients with mFI ≥ 1 (n = 298) were more likely to have higher rates of reoperation (13.4% vs. 8.7%, p = 0.045), medical complications (20.5% vs. 9.2%, p < 0.001), surgical complications (13.8% vs. 8.4%, p = 0.024), discharge to non-home facility (DNHF) (24.8% vs. 13.3%, p < 0.001), and prolonged length of hospitalization (7.3 ± 6.8 days vs. 5.6 ± 5.0, p = 0.003). Moreover, mFI = 1-3 was also associated with higher BMI, non-white race, high ASA, and older age (all p < 0.05). Upon adjusting for age, BMI, race, ASA score, and surgical site, multivariate regression analysis demonstrated that higher mFI (treated as a continuous variable) was associated with higher odds of medical complications (OR = 1.630, CI = 1.153-2.308, p = 0.006), surgical complications (OR = 1.594, CI = 1.042-2.438, p < 0.031), and LOS ≥ 10 days (OR = 1.609, CI = 1.176-2.208, p = 0.003). In conclusion, the 5-item mFI can be an independent predictor of several important short-term surgical outcomes following intradural resection of skull base lesions, warranting further investigations into its clinical utility.

Indexed as

FrailtyAdultAgedFemaleHumansMaleMiddle AgedPatient DischargePostoperative ComplicationsReoperationRetrospective StudiesTreatment OutcomeFrailtyModified frailty indexMorbidityNSQIPSkull base

Identifiers

PMID34373037
PMCPMC8590585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.