Evidence map›Paper›PMID 34372968›Full record

ArticleeLife2021

Twisting of the zebrafish heart tube during cardiac looping is a

Federico Tessadori, Erika Tsingos, Enrico Sandro Colizzi, Fabian Kruse, Susanne C van den Brink, Malou van den Boogaard, Vincent M Christoffels, Roeland Mh Merks, Jeroen Bakkers

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. TheCells · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Zebrafish in Cardiovascular Disease Research: from Model to Application.International journal of biological sciences · 2026
    Review
  7. Article
  8. Article
  9. The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025
    Review
  10. Article
  11. Journal of cardiovascular development and disease · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Review
  19. Modeling Human Cardiac Arrhythmias: Insights from Zebrafish.Journal of cardiovascular development and disease · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Federico TessadoriHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-9975-0546
Erika TsingosMathematical Institute, Leiden University, Leiden, Netherlands.ORCID https://orcid.org/0000-0002-7267-160X
Enrico Sandro ColizziMathematical Institute, Leiden University, Leiden, Netherlands.ORCID http://orcid.org/0000-0003-1709-4499
Fabian KruseHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands.
Susanne C van den BrinkHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0003-3683-7737
Malou van den BoogaardAmsterdam UMC, University of Amsterdam, Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.
Vincent M ChristoffelsAmsterdam UMC, University of Amsterdam, Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.ORCID https://orcid.org/0000-0003-4131-2636
Roeland Mh MerksMathematical Institute, Leiden University, Leiden, Netherlands.
Jeroen BakkersHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-9418-0422
University Medical Center Utrecht · NLLeiden University · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is the first organ to display visible left-right asymmetries through its left-sided positioning and rightward looping. Here, we present a new zebrafish loss-of-function allele for

Indexed as

AnimalsBody PatterningEmbryo, NonmammalianHeartOrganogenesisTranscription FactorsZebrafishZebrafish Proteinstbx5a protein, zebrafishTranscription FactorsZebrafish Proteinsasymmetrycell biologycell trackingchiraldevelopmental biologyheartlateralityT-boxzebrafish

Identifiers

PMID34372968
PMCPMC8354640
OpenAlexW3186447512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.