ArticleDiagnostic pathology2021
Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis.
Article in Diagnostic pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Advances in Minimally Invasive Diagnosis and Treatment Procedures for Pancreaticobiliary Maljunction: A Narrative Review.Digestive diseases and sciences · 2026Review
- Pancreaticobiliary Maljunction Independently Predicts Early Recurrence after Surgical Resection for Gallbladder Carcinoma without Hepaticojejunostomy: A Propensity-Weighted Cohort Study.Annals of surgical oncology · 2026Article
- Pressure Tactic: Pancreato-Biliary Maljunction-Newer Insights into Pathophysiology and Management.Digestive diseases and sciences · 2025Article
- Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.Medical review (2021) · 2024Review
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- Gallbladder cancer.Nature reviews. Disease primers · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreaticobiliary maljunction (PBM) is a condition characterized by chronic inflammation due to refluxed pancreatic juice into the biliary tract that is associated with an elevated risk of biliary tract cancer. DNA double-strand breaks (DSBs) are considered the most serious form of DNA damage. DSBs are provoked by inflammatory cell damage and are recognized as an important oncogenic event in several cancers. This study used γ-H2AX, an established marker of DSB formation, to evaluate the impact of DNA damage on carcinogenesis in PBM.
methodsWe investigated γ-H2AX expression immunohistochemically in gallbladder epithelium samples obtained from 71 PBM cases and 19 control cases.
resultsFourteen PBM cases with gallbladder adenocarcinoma were evaluated at non-neoplastic regions. A wide range of nuclear γ-H2AX staining was detected in all PBM and control specimens. γ-H2AX expression was significantly higher in PBM cases versus controls (median γ-H2AX-positive proportion: 14.4 % vs. 4.4 %, p = 0.001). Among the PBM cases, γ-H2AX expression was significantly higher in patients with carcinoma than in those without (median γ-H2AX-positive proportion: 21.4 % vs. 11.0 %, p = 0.031).
conclusionsDSBs occurred significantly more abundantly in the PBM gallbladder mucosa, especially in the context of cancer, indicating an involvement in PBM-related carcinogenesis.
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Registered trials
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