Evidence map›Paper›PMID 34372793›Full record

ArticleBMC infectious diseases2021

Age and sex distribution of Mycobacterium tuberculosis infection and rifampicin resistance in Myanmar as detected by Xpert MTB/RIF.

Marva Seifert, Hlaing Thazin Aung, Nicole Besler, Victoria Harris, Tin Tin Mar, Rebecca E Colman, Timothy C Rodwell, Si Thu Aung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Contributions of GeneXpertThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Marva Seifert *University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA. mseifert@ucsd.edu.
Hlaing Thazin Aung *Clinton Health Access Initiative, Yangon, Myanmar.
Nicole BeslerUniversity of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Victoria HarrisFIND, the global alliance for diagnostics, Campus Biotech, 9 Chemin des Mines -, 1202, Geneva, Switzerland.
Tin Tin MarMinistry of Health and Sports, Office No. 4, Naypyitaw, Myanmar.
Rebecca E ColmanUniversity of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Timothy C RodwellUniversity of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Si Thu AungMinistry of Health and Sports, Office No. 4, Naypyitaw, Myanmar.
University of California, San Diego · USMinistry of Health and Sports · MMFoundation for Innovative New Diagnostics · CH

Funding

Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
NHLBI NIH HHS T32 HL134632
6 · The paper itself

Abstract

backgroundDetection of tuberculosis disease (TB) and timely identification of Mycobacterium tuberculosis (Mtb) strains that are resistant to treatment are key to halting tuberculosis transmission, improving treatment outcomes, and reducing mortality.

methodsWe used 332,657 Xpert MTB/RIF assay results, captured as part of the Myanmar Data Utilization Project, to characterize Mtb test positivity and rifampicin resistance by both age and sex, and to evaluate risk factors associated with rifampicin resistance.

resultsOverall, 70% of individuals diagnosed with TB were males. Test positivity was higher among males (47%) compared to females (39%). The highest positivity by age occurred among individuals aged 16-20, with test positivity for females (65%) higher than for males (57%). Although a greater absolute number of males were rifampicin resistant, a greater proportion of females (11.4%) were rifampicin resistant as compared to males (9.3%). In the multivariate model, history of previous treatment, age less than 30, testing in the Yangon region, and female sex were significantly positively associated with rifampicin resistance after adjusting for HIV status and year test was performed.

conclusionsOur results indicate that young adults were more likely to test positive for TB and be identified as rifampicin resistant compared to older adults.

Indexed as

Antibiotics, AntitubercularMycobacterium tuberculosisTuberculosisTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryAgedDrug Resistance, BacterialFemaleHumansMaleMyanmarRifampinSensitivity and SpecificitySex DistributionYoung AdultAntibiotics, AntitubercularRifampinAgeMyanmarMycobacterium tuberculosisRifampicin resistanceSexXpert MTB/RIF

Identifiers

PMID34372793
PMCPMC8351356
OpenAlexW3189263648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.