Evidence map›Paper›PMID 34372701›Full record

ArticlemBio2021

Evolution towards Virulence in a

Matthew M Schaefers, Benjamin X Wang, Nicole M Boisvert, Sarah J Martini, Sarah L Bonney, Christopher W Marshall, Michael T Laub, Vaughn S Cooper, Gregory P Priebe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. mBio · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthew M SchaefersDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Benjamin X WangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Nicole M BoisvertDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Sarah J MartiniDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Sarah L BonneyDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Christopher W MarshallMicrobiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Michael T LaubDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Vaughn S CooperMicrobiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Gregory P PriebeDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USUniversity of Pittsburgh · USHoward Hughes Medical Institute · USMassachusetts Institute of Technology · US

Funding

Cell Cycle Regulation in Caulobacter CrescentusR01GM082899 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LAUB, MICHAEL · 2008 to 2020
$3.8M
Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM082899NIGMS NIH HHS R01 GM110444
6 · The paper itself

Abstract

Bacteria in the Burkholderia cepacia complex (BCC) are significant pathogens for people with cystic fibrosis (CF) and are often extensively antibiotic resistant. Here, we assess the impacts of clinically observed mutations in

Indexed as

Evolution, MolecularPoint MutationAnimalsBacterial ProteinsBurkholderiaBurkholderia cepacia complexBurkholderia InfectionsFemaleHistidine KinaseHumansLungMacrophagesMiceMice, Inbred C57BLPhenotypePneumoniaBacterial ProteinsFixL protein, BacteriaHistidine KinaseBurkholderiaevolutiontwo-component regulatory systemsvirulence regulation

Identifiers

PMID34372701
PMCPMC8406202
OpenAlexW3192431244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.