Evidence map›Paper›PMID 34372624›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2021

The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.

Xichang Wang, Haoyu Wang, Li Yan, Lihui Yang, Yuanming Xue, Jing Yang, Yongli Yao, Xulei Tang, Nanwei Tong, Guixia Wang and 25 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology and metabolism (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 1 country.

Xichang WangDepartment of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
Haoyu WangDepartment of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
Li YanDepartment of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Lihui YangDepartment of Endocrinology and Metabolism, People's Hospital of the Tibet Autonomous Region, Lhasa, Tibet, China.
Yuanming XueDepartment of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China.
Jing YangDepartment of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Yongli YaoDepartment of Endocrinology, Qinghai Provincial People's Hospital, Xining, China.
Xulei TangDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.
Nanwei TongDepartment of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Guixia WangDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
Jinan ZhangDepartment of Endocrinology, Health Science Affiliated Zhoupu Hosipital, Shanghai University of Medicine, Shanghai, China.
Youmin WangDepartment of Endocrinology, The First Hospital of An Hui Medical University, Hefei, China.
Jianming BaDepartment of Endocrinology, Chinese PLA General Hospital, Beijing, China.
Bing ChenDepartment of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Jianling DuDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lanjie HeDepartment of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China.
Xiaoyang LaiDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yanbo LiDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhaoli YanDepartment of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University. Hohhot, China.
Eryuan LiaoDepartment of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Chao LiuResearch Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Libin LiuDepartment of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China.
Guijun QinDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Yingfen QinDepartment of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huibiao QuanDepartment of Endocrinology, Hainan General Hospital, Haikou, China.
Bingyin ShiDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Hui SunDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Qiao ZhangDepartment of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China.
Lihui ZhangDepartment of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jun ZhuDepartment of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Mei ZhuDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Yongze LiDepartment of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
Weiping TengDepartment of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
Zhongyan ShanDepartment of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
First Hospital of China Medical University · CNHarbin Medical University · CNAnhui Medical University · CNArmy Medical University · CNCentral South University · CNChinese PLA General Hospital · CNDalian Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFirst Affiliated Hospital of Zhengzhou University · CNFirst Hospital of Lanzhou University · CNFirst People's Hospital of Yunnan Province · CNFujian Medical University · CNGuangxi Medical University · CNGuiyang Medical University · CNHainan General Hospital · CNHebei Medical University · CNInner Mongolia Medical University · CNJilin University · CNNanchang University · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension.

methodsBased on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017.

resultsThe prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years.

conclusionThe prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.

Indexed as

HypertensionHypothyroidismAdolescentAdultAgedBlood PressureFemaleHumansMaleReference ValuesThyrotropinUnited StatesThyrotropinBlood pressureHypertensionHypothyroidism

Identifiers

PMID34372624
PMCPMC8419610
OpenAlexW3192655076

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.