Evidence map›Paper›PMID 34372594›Full record

ArticleViruses2021

STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV).

Olivier Escaffre, Terry L Juelich, Natasha Neef, Shane Massey, Jeanon Smith, Trevor Brasel, Jennifer K Smith, Birte Kalveram, Lihong Zhang, David Perez and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. CD4Nature immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Olivier EscaffreDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Terry L JuelichDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Natasha NeefXTR Toxicologic Pathology Services LLC, Sterling, VA 20165, USA.
Shane MasseyOffice of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Jeanon SmithOffice of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Trevor BraselOffice of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Jennifer K SmithDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Birte KalveramDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Lihong ZhangDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
David PerezTexas A&M University Division of Research, Texas A&M University, College Station, TX 77843, USA.
Tetsuro IkegamiDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.ORCID 0000-0001-8318-2783
Alexander N FreibergDepartment of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Jason E ComerOffice of Regulated Nonclinical Studies, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · USTexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently there is no FDA-licensed vaccine or therapeutic against Sudan ebolavirus (SUDV) infections. The largest ever reported 2014-2016 West Africa outbreak, as well as the 2021 outbreak in the Democratic Republic of Congo, highlight the critical need for countermeasures against filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would greatly add to the screening of antivirals and vaccines. Here, we infected signal transducer and activator of transcription-1 knock out (STAT-1 KO) mice with five different wildtype filoviruses to determine susceptibility. SUDV and Marburg virus (MARV) were the most virulent, and caused 100% or 80% lethality, respectively. Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Taï Forest ebolavirus (TAFV) caused 40%, 20%, and no mortality, respectively. Further characterization of SUDV in STAT-1 KO mice demonstrated lethality down to 3.1 × 10

Indexed as

Disease Models, AnimalMice, KnockoutAmidesAnimalsAntibodies, ViralAntiviral AgentsEbolavirusFemaleHemorrhagic Fever, EbolaMaleMicePyrazinesSTAT1 Transcription FactorViral ProteinsAmidesAntibodies, ViralAntiviral AgentsfavipiravirPyrazinesStat1 protein, mouseSTAT1 Transcription FactorViral Proteinsanimal modelebolavirusfilovirusSTAT-1 knockout miceSUDV

Identifiers

PMID34372594
PMCPMC8310124
OpenAlexW3184514644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.