Evidence map›Paper›PMID 34372579›Full record

ArticleViruses2021

Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk.

Chathura D Suraweera, Mark G Hinds, Marc Kvansakul

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chathura D SuraweeraLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0001-9185-6063
Mark G HindsBio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0002-2856-5375
Marc KvansakulLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, VIC 3086, Australia.
La Trobe University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous viruses have evolved sophisticated countermeasures to hijack the early programmed cell death of host cells in response to infection, including the use of proteins homologous in sequence or structure to Bcl-2. Orf virus, a member of the

Indexed as

ApoptosisApoptosis Regulatory ProteinsCrystallography, X-RayHumansOrf virusParapoxvirusProtein BindingProtein ConformationProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Viral ProteinsApoptosis Regulatory ProteinsBBC3 protein, humanBCL2 protein, humanHRK protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Viral ProteinsapoptosisBcl-2 proteinsorf viruspoxvirusX-ray crystallography

Identifiers

PMID34372579
PMCPMC8310162
OpenAlexW3178902253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.