Evidence map›Paper›PMID 34372521›Full record

ArticleViruses2021

Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution.

Hung-Da Tung, Pei-Lun Lee, Jyh-Jou Chen, Hsing-Tao Kuo, Ming-Jen Sheu, Chun-Ta Cheng, Tang-Wei Chuang, Hsu-Ju Kao, Yu-Hsun Wu, Mai-Gio Pang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hung-Da TungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.ORCID 0000-0001-9247-6820
Pei-Lun LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Jyh-Jou ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.ORCID 0000-0002-6344-320X
Hsing-Tao KuoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Yongkang, Tainan 71004, Taiwan.ORCID 0000-0002-5841-974X
Ming-Jen SheuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Yongkang, Tainan 71004, Taiwan.
Chun-Ta ChengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Tang-Wei ChuangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Hsu-Ju KaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Yu-Hsun WuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Mai-Gio PangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Cheng-Heng LinDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Chia-Yi HouDepartment of Clinical Pathology, Chi-Mei Medical Center, Liouying, Tainan 73657, Taiwan.
Hsin-Hua TsaiDepartment of Clinical Pathology, Chi-Mei Medical Center, Yongkang, Tainan 71004, Taiwan.
Li-Ching WuDepartment of Clinical Pathology, Chi-Mei Medical Center, Yongkang, Tainan 71004, Taiwan.
Chuan LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Hospital, Chiali, Tainan 72263, Taiwan.
Chi Mei Medical Center · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major HCV GTs in Taiwan were GT 1b and 2 with very rare GT 6 except in injection drug users (IDUs), and subtype 6a is the main GT 6 subtype among IDUs. Recently, we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. A total of 3022 (1343 men and 1679 women) HCV viremic patients were enrolled. Subtypes of GT 6 were determined by sequencing of core/E1 and nonstructural protein 5B in 322 of 518 GT 6 patients. The overall GT 6 prevalence rate was 17.1% (518/3022), with higher prevalence districts (>25%) located in northern Tainan. A novel 6g-related subtype is the most prevalent subtype (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%). The high GT 6 prevalence in Tainan was mainly due to a novel 6g-related subtype and 6w. These two subtypes could be indigenous in Tainan with characteristic geographic distribution.

Indexed as

GenotypePhylogenyAgedFemaleGeographyHepacivirusHepatitis CHumansMaleMiddle AgedPrevalenceTaiwanViral Nonstructural ProteinsViremiaViral Nonstructural Proteinsgenotypehepatitis C virusinjection drug userphylogenetic analysis

Identifiers

PMID34372521
PMCPMC8310057
OpenAlexW3180517879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.