Evidence map›Paper›PMID 34372446›Full record

ArticleSensors (Basel, Switzerland)2021

Time Evolution of the Skin-Electrode Interface Impedance under Different Skin Treatments.

Brendan B Murphy, Brittany H Scheid, Quincy Hendricks, Nicholas V Apollo, Brian Litt, Flavia Vitale

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Sericin Electrodes with Self-Adhesive Properties for Biosignaling.ACS biomaterials science & engineering · 2025
    Article
  15. Article
  16. Article
  17. Motion artefact management for soft bioelectronics.Nature reviews bioengineering · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brendan B MurphyDepartment of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, 210 S. 33rd Street, Philadelphia, PA 19104, USA.ORCID 0000-0003-3021-6286
Brittany H ScheidDepartment of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, 210 S. 33rd Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-8528-0085
Quincy HendricksDepartment of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, 210 S. 33rd Street, Philadelphia, PA 19104, USA.
Nicholas V ApolloCenter for Neuroengineering & Therapeutics, 301 Hayden Hall, University of Pennsylvania, 240 S. 33rd Street, Philadelphia, PA 19104, USA.
Brian LittDepartment of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, 210 S. 33rd Street, Philadelphia, PA 19104, USA.
Flavia VitaleDepartment of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, 210 S. 33rd Street, Philadelphia, PA 19104, USA.

Funding

Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
Neurophysiologically Based Brain State Tracking & Modulation in Focal EpilepsyUH3NS095495 · NINDS · MAYO CLINIC ROCHESTER · PI WORRELL, GREGORY A · 2019 to 2021
$2.8M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
NICHD NIH HHS K12 HD073945NIH HHS K12HD073945NINDS NIH HHS R01NS099348NINDS NIH HHS UH3NS 95495-4
6 · The paper itself

Abstract

A low and stable impedance at the skin-electrode interface is key to high-fidelity acquisition of biosignals, both acutely and in the long term. However, recording quality is highly variable due to the complex nature of human skin. Here, we present an experimental and modeling framework to investigate the interfacial impedance behavior, and describe how skin interventions affect its stability over time. To illustrate this approach, we report experimental measurements on the skin-electrode impedance using pre-gelled, clinical-grade electrodes in healthy human subjects recorded over 24 h following four skin treatments: (i) mechanical abrasion, (ii) chemical exfoliation, (iii) microporation, and (iv) no treatment. In the immediate post-treatment period, mechanical abrasion yields the lowest initial impedance, whereas the other treatments provide modest improvement compared to untreated skin. After 24 h, however, the impedance becomes more uniform across all groups (<20 kΩ at 10 Hz). The impedance data are fitted with an equivalent circuit model of the complete skin-electrode interface, clearly identifying skin-level versus electrode-level contributions to the overall impedance. Using this model, we systematically investigate how time and treatment affect the impedance response, and show that removal of the superficial epidermal layers is essential to achieving a low, long-term stable interface impedance.

Indexed as

SkinElectric ImpedanceElectrodesHumansequivalent circuit modelskin–electrode interfaceskin impedanceskin treatmentwearable sensors

Identifiers

PMID34372446
PMCPMC8348734

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.