ArticleSensors (Basel, Switzerland)2021
Noise Sources and Requirements for Confocal Raman Spectrometers in Biosensor Applications.
Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Evaluating Limits of Machine Learning-Assisted Raman Spectroscopy in Classification of Biological Samples.ACS omega · 2026Article
- Evaluating Limits of Machine Learning-Assisted Raman Spectroscopy in Classification of Biological Samples.bioRxiv : the preprint server for biology · 2026Article
- Transfer-Learning Deep Raman Models Using Semiempirical Quantum Chemistry.Journal of chemical information and modeling · 2025Article
- Biosensors, Artificial Intelligence Biosensors, False Results and Novel Future Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Noise learning of instruments for high-contrast, high-resolution and fast hyperspectral microscopy and nanoscopy.Nature communications · 2024Article
- Performance assessment of probe-based Raman spectroscopy systems for biomedical analysis.Biomedical optics express · 2023Article
- Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.Journal of biophotonics · 2023Review
- Emergence of Raman Spectroscopy as a Probing Tool for Theranostics.Nanotheranostics · 2023Review
- Label-Free Sensing with Metal Nanostructure-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis.ACS applied nano materials · 2022Review
- Testing Raman spectroscopy as a diagnostic approach for Lyme disease patients.Frontiers in cellular and infection microbiology · 2022Article
- Quantitative, Temperature-Calibrated and Real-Time Glucose Biosensor Based on Symmetrical-Meandering-Type Resistor and Intertwined Capacitor Structure.Biosensors · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Raman spectroscopy probes the biochemical composition of samples in a non-destructive, non-invasive and label-free fashion yielding specific information on a molecular level. Nevertheless, the Raman effect is very weak. The detection of all inelastically scattered photons with highest efficiency is therefore crucial as well as the identification of all noise sources present in the system. Here we provide a study for performance comparison and assessment of different spectrometers for confocal Raman spectroscopy in biosensor applications. A low-cost, home-built Raman spectrometer with a complementary metal-oxide-semiconductor (CMOS) camera, a middle price-class mini charge-coupled device (CCD) Raman spectrometer and a laboratory grade confocal Raman system with a deeply cooled CCD detector are compared. It is often overlooked that the sample itself is the most important "optical" component in a Raman spectrometer and its properties contribute most significantly to the signal-to-noise ratio. For this purpose, different representative samples: a crystalline silicon wafer, a polypropylene sample and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.