Evidence map›Paper›PMID 34372111›Full record

ArticlePolymers2021

3D-Printable Hierarchical Nanogel-GelMA Composite Hydrogel System.

Guangyue Zu, Marnix Meijer, Olga Mergel, Heng Zhang, Patrick van Rijn

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  7. Materials today. Bio · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guangyue ZuUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, W. J. Kolff Institute for Biomedical Engineering and Materials Science, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Marnix MeijerUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, W. J. Kolff Institute for Biomedical Engineering and Materials Science, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Olga MergelUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, W. J. Kolff Institute for Biomedical Engineering and Materials Science, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Heng ZhangUniversity of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Patrick van RijnUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, W. J. Kolff Institute for Biomedical Engineering and Materials Science, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
University of Groningen · NLUniversity Medical Center Groningen · NL

Funding

China Sponsorship Council 201706890012
6 · The paper itself

Abstract

The strength of the extracellular matrix (ECM) is that it is hierarchical in terms of matrix built-up, matrix density and fiber structure, which allows for hormones, cytokines, and other small biomolecules to be stored within its network. The ECM-like hydrogels that are currently used do not possess this ability, and long-term storage, along with the need for free diffusion of small molecules, are generally incompatible requirements. Nanogels are able to fulfill the additional requirements upon successful integration. Herein, a stable hierarchical nanogel-gelatin methacryloyl (GelMA) composite hydrogel system is provided by covalently embedding nanogels inside the micropore network of GelMA hydrogel to allow a controlled local functionality that is not found in a homogenous GelMA hydrogel. Nanogels have emerged as a powerful tool in nanomedicine and are highly versatile, due to their simplicity of chemical control and biological compatibility. In this study, an

Indexed as

3D printingECMGelMA hydrogelshierarchical networknanogels

Identifiers

PMID34372111
PMCPMC8348806
OpenAlexW3184518925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.