Evidence map›Paper›PMID 34371954›Full record

ArticleNutrients2021

Fast Anxiolytic-Like Effect Observed in the Rat Conditioned Defensive Burying Test, after a Single Oral Dose of Natural Protein Extract Products.

Thomas Freret, Stacy Largilliere, Gerald Nee, Melanie Coolzaet, Sophie Corvaisier, Michel Boulouard

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Biology · 2026
    Article
  2. Anxiolytic Effects ofFoods (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas FreretUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.ORCID 0000-0002-4446-4451
Stacy LargilliereUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.
Gerald NeeUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.
Melanie CoolzaetUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.
Sophie CorvaisierUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.
Michel BoulouardUNICAEN, INSERM, COMETE, Cyceron, CHU Caen, Normandie University, 14000 Caen, France.
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety appears among the most frequent psychiatric disorders. During recent years, a growing incidence of anxiety disorders can be attributed, at least in part, to the modification of our eating habits. To treat anxiety disorders, clinicians use benzodiazepines, which unfortunately display many side effects. Herein, the anxiolytic-like properties of two natural products (αS1-casein hydrolysate and Gabolysat

Indexed as

AnimalsAnti-Anxiety AgentsAnxietyBehavior, AnimalCaseinsConditioning, PsychologicalDiazepamFish ProteinsMaleProtein HydrolysatesRatsAnti-Anxiety Agentscasein hydrolysateCaseinsDiazepamFish ProteinsProtein Hydrolysatesanxietyburying testfish protein hydrolysaterodent

Identifiers

PMID34371954
PMCPMC8308885
OpenAlexW3186515749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.