Evidence map›Paper›PMID 34371890›Full record

Observational studyNutrients2021

Glucose Fluctuation and Severe Internal Carotid Artery Siphon Stenosis in Type 2 Diabetes Patients.

Futoshi Eto, Kazuo Washida, Masaki Matsubara, Hisashi Makino, Akio Takahashi, Kotaro Noda, Yorito Hattori, Yuriko Nakaoku, Kunihiro Nishimura, Kiminori Hosoda and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Futoshi EtoDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.ORCID 0000-0001-5030-1598
Kazuo WashidaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Masaki MatsubaraDivision of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Hisashi MakinoDivision of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Akio TakahashiDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Kotaro NodaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.ORCID 0000-0003-2690-4318
Yorito HattoriDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Yuriko NakaokuDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.ORCID 0000-0002-3100-574X
Kunihiro NishimuraDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.ORCID 0000-0002-0639-0949
Kiminori HosodaDivision of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita 564-8565, Japan.ORCID 0000-0002-7102-4048
National Cerebral and Cardiovascular Center · JP

Funding

Japan Agency for Medical Research and Development 18ek0210104h0001
6 · The paper itself

Abstract

The impact of glucose fluctuation on intracranial artery stenosis remains to be elucidated. This study aimed to investigate the association between glucose fluctuation and intracranial artery stenosis. This was a cross-sectional study of type 2 diabetes mellitus (T2DM) patients equipped with the FreeStyle Libre Pro continuous glucose monitoring system (Abbott Laboratories) between February 2019 and June 2020. Glucose fluctuation was evaluated according to the standard deviation (SD) of blood glucose, coefficient of variation (%CV), and mean amplitude of glycemic excursions (MAGE). Magnetic resonance angiography was used to evaluate the degree of intracranial artery stenosis. Of the 103 patients, 8 patients developed severe internal carotid artery (ICA) siphon stenosis (≥70%). SD, %CV, and MAGE were significantly higher in the severe stenosis group than in the non-severe stenosis group (<70%), whereas there was no significant intergroup difference in the mean blood glucose and HbA1c. Multivariable logistic regression analysis adjusted for sex showed that SD, %CV, and MAGE were independent factors associated with severe ICA siphon stenosis. In conclusion, glucose fluctuation is significantly associated with severe ICA siphon stenosis in T2DM patients. Thus, glucose fluctuation can be a target of preventive therapies for intracranial artery stenosis and ischemic stroke.

Indexed as

AgedBlood GlucoseBlood Glucose Self-MonitoringCarotid Artery, InternalCarotid StenosisCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansIntracranial Arterial DiseasesMagnetic Resonance AngiographyMaleRetrospective StudiesRisk FactorsBlood Glucosecontinuous glucose monitoringglucose fluctuationintracranial artery stenosismean amplitude of glycemic excursionsstandard deviation

Identifiers

PMID34371890
PMCPMC8308661
OpenAlexW3179744433

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.