Evidence map›Paper›PMID 34371846›Full record

ReviewNutrients2021

Vitamin D, Its Role in Recovery after Muscular Damage Following Exercise.

Alberto Caballero-García, Alfredo Córdova-Martínez, Néstor Vicente-Salar, Enrique Roche, Daniel Pérez-Valdecantos

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  4. Nitric-Oxide-Inducing Factors on Vitamin D Changes in Older People Susceptible to Suffer from Sarcopenia.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alberto Caballero-GarcíaDepartment of Anatomy and Radiology, Health Sciences Faculty, GIR: "Physical Exercise and Aging", Campus Universitario "Los Pajaritos", University of Valladolid, 42004 Soria, Spain.
Alfredo Córdova-MartínezDepartment of Biochemistry, Molecular Biology and Physiology, Health Sciences Faculty, GIR: "Physical Exercise and Aging", Campus Universitario "Los Pajaritos", University of Valladolid, 42004 Soria, Spain.ORCID 0000-0003-0236-2817
Néstor Vicente-SalarDepartment of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0003-2276-7205
Enrique RocheDepartment of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0001-5128-1672
Daniel Pérez-ValdecantosDepartment of Biochemistry, Molecular Biology and Physiology, Health Sciences Faculty, GIR: "Physical Exercise and Aging", Campus Universitario "Los Pajaritos", University of Valladolid, 42004 Soria, Spain.ORCID 0000-0002-6916-608X
Universidad de Valladolid · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aside from its role in bone metabolism, vitamin D is a key immunomodulatory micronutrient. The active form of vitamin D (1,25(OH)D) seems to modulate the innate immune system through different mechanisms. The vitamin is involved in the differentiation of monocytes into macrophages, increasing the phagocytic and chemotactic functions of these cells. At the same time, vitamin D enables efferocytosis and prevents immunopathology. In addition, vitamin D is involved in other processes related to immune function, such as inflammation. Regarding muscle tissue, vitamin D plays an active role in muscle inflammatory response, protein synthesis, and regulation of skeletal muscle function. Two mechanisms have been proposed: A direct role of 1,25(OH)D binding to vitamin D receptors (VDRs) in muscle cells and the modulation of calcium transport in the sarcoplasmic reticulum. This second mechanism needs additional investigation. In conclusion, vitamin D seems to be effective in cases of deficiency and/or if there is a great muscular commitment, such as in high intensity exercises.

Indexed as

Cell DifferentiationExerciseHigh-Intensity Interval TrainingHumansImmunomodulationInflammationMacrophagesMonocytesMuscle, SkeletalMuscular DiseasesReceptors, CalcitriolVitamin DReceptors, CalcitriolVitamin Dexerciseimmunomodulationinflammationvitamin D

Identifiers

PMID34371846
PMCPMC8308579
OpenAlexW3179482867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.